Decreased paraoxonase-1 activity is a risk factor for ischemic stroke in Koreans

Paraoxonase-1 (PON1) is an enzyme associated with HDL in blood and it is considered as an anti-oxidant factor due to its capability to prevent lipid oxidation. In vivo mouse studies also have shown that PON1 is one of the genetic risk factors contributing to atherosclerosis. In this study, we evalua...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2007-12, Vol.364 (1), p.157-162
Main Authors: Kim, No Soo, Kang, Kyungwon, Cha, Min Ho, Kang, Bong-Joo, Moon, Jinseok, Kang, Byoung Kab, Yu, Byeong-Chan, Kim, Yoon-Sik, Choi, Sun Mi, Bang, Ok-Sun
Format: Article
Language:English
Subjects:
Aged
Aryldialkylphosphatase - blood
Blood lipids
Cholesterol, HDL - blood
Female
Humans
Korea - epidemiology
Korean
Male
Middle Aged
PON1
Risk Factors
Stroke
Stroke - etiology
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Summary:Paraoxonase-1 (PON1) is an enzyme associated with HDL in blood and it is considered as an anti-oxidant factor due to its capability to prevent lipid oxidation. In vivo mouse studies also have shown that PON1 is one of the genetic risk factors contributing to atherosclerosis. In this study, we evaluated the serum PON1 activities of sex–age matched Korean healthy control and ischemic stroke patients, and investigated the association of PON1 activity with other metabolic parameters. Statistical analyses revealed that PON1 activity and HDL_cholesterol (HDL_C) in stroke patients were significantly decreased when compared with those of healthy control. Additionally, PON1 activity was negatively correlated with age, whereas it was positively correlated with HDL_C in a stroke group. Overall, the results of this study indicated that decreased serum PON1 activity should be considered as a risk factor for ischemic stroke in Koreans.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2007.09.119