UCP2 A55V variant is associated with obesity and related phenotypes in an aboriginal community in Taiwan

Objective: Human uncoupling proteins 2 and 3 (UCP2 and UCP3) are two mitochondrial proteins that are involved in the control of metabolism of fatty acid and possibly protect against oxidative damage. The aim of this study was to analyze genetic associations of four polymorphisms of the UCP2 and UCP3...

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Bibliographic Details
Published in:International Journal of Obesity 2007-11, Vol.31 (11), p.1746-1752
Main Authors: Wang, T.N, Huang, M.C, Lin, H.L, Hsiang, C.H, Ko, A.M.J, Chang, W.T, Ko, Y.C
Format: Article
Language:English
Subjects:
Aged
alleles
Analysis
anthropometric measurements
Anthropometry
Biological and medical sciences
Body fat
Body mass index
Cholesterol
Cholesterol - blood
Diabetes
elderly
Epidemiology
Fasting - blood
Fatty acids
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
genetic variance
Genotype
Haplotypes
Health aspects
Health Promotion and Disease Prevention
Hospitals
Humans
Indigenous peoples
Insulin
Insulin - blood
Internal Medicine
Ion Channels - genetics
Leptin
Leptin - blood
Linkage Disequilibrium
lipid metabolism
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Middle Aged
Mitochondrial Proteins - genetics
Native peoples
Obesity
Obesity - blood
Obesity - ethnology
Obesity - genetics
original-article
Overweight
Phenotype
Plasma
Polymorphism
Polymorphism, Single Nucleotide
Proteins
Public Health
Questionnaires
Research methods
risk factors
Taiwan - epidemiology
Triglycerides
Triglycerides - blood
UCP2 A55V variant
Uncoupling Protein 2
Uncoupling Protein 3
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Objective: Human uncoupling proteins 2 and 3 (UCP2 and UCP3) are two mitochondrial proteins that are involved in the control of metabolism of fatty acid and possibly protect against oxidative damage. The aim of this study was to analyze genetic associations of four polymorphisms of the UCP2 and UCP3 genes with insulin, leptin concentration and obesity in Taiwan aborigines. Research methods: Four polymorphisms were compared in 324 obese (body mass index (BMI) ⩾30 kg/m 2 ) and overweight (30>BMI ⩾25 kg/m 2 ) subjects, and 114 normal weight subjects (BMI
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0803648