Ovarian clear cell carcinoma associated with endometriosis: a case report with immunohistochemical study

Endometriosis is a frequent benign gynecological disease; nonetheless, it can demonstrate some aspects that resemble malignant disease. Malignant transformation of endometriosis occurs mainly in the ovary. A rare case of transition between typical endometriosis and clear cell carcinoma with immunohi...

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Bibliographic Details
Published in:European journal of gynaecological oncology 2007, Vol.28 (5), p.403-405
Main Authors: Murta, E F C, Nomelini, R S, Ferreira, F A, Lima, M A
Format: Article
Language:English
Subjects:
Adenocarcinoma, Clear Cell - complications
Adenocarcinoma, Clear Cell - pathology
Adult
Biomarkers, Tumor - analysis
Endometriosis - complications
Endometriosis - pathology
Female
Humans
Immunohistochemistry
Ovarian Cysts - complications
Ovarian Neoplasms - complications
Ovarian Neoplasms - pathology
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Summary:Endometriosis is a frequent benign gynecological disease; nonetheless, it can demonstrate some aspects that resemble malignant disease. Malignant transformation of endometriosis occurs mainly in the ovary. A rare case of transition between typical endometriosis and clear cell carcinoma with immunohistochemical study is presented. The patient, a 30-year-old Caucasian woman (para 0), was diagnosed with endometriosis ten years before. Six months later she developed a left cystic ovarian tumor (58 cm3) that persisted after two ultrasounds in a four-month period. Tumor markers were normal (CA125, CA 15.3, CA 19.9, alpha-fetoprotein, carcinoembrionary antigen A1). There was no ascites. The left ovarian mass was removed by laparotomy and endometriosis in continuity with carcinoma positive for cytokeratin 7 and estrogen receptor was revealed. CD10 was positive in the stromal cells of the endometriosis. Clear cell carcinoma grade 3 was diagnosed. In conclusion, although a rare event, the association of typical endometriosis and clear cell carcinoma of the ovary should be kept in mind, mainly in patients with a persistent ovarian cyst.
ISSN:0392-2936