Association of Plasma Levels of F11 Receptor/Junctional Adhesion Molecule-A (F11R/JAM-A) With Human Atherosclerosis

• Published in: Journal of the American College of Cardiology 2007-10, Vol.50 (18), p.1768-1776
• Main Authors: Cavusoglu, Erdal, MD, Kornecki, Elizabeth, PhD, Sobocka, Malgorzata B., PhD, Babinska, Anna, PhD, Ehrlich, Yigal H., PhD, Chopra, Vineet, MD, Yanamadala, Sunitha, PhD, Ruwende, Cyril, MD, PhD, Salifu, Moro O., MD, Clark, Luther T., MD, FACC, Eng, Calvin, MD, FACC, Pinsky, David J., MD, FACC, Marmur, Jonathan D., MD, FACC
• Format: Article
• Language: English
• Subjects: Aged; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Biomarkers; Biomarkers - blood; Blood and lymphatic vessels; Blood platelets; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Case-Control Studies; Cell adhesion & migration; Cell Adhesion Molecules - blood; Coronary Angiography; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - etiology; Diabetes; Enzyme-Linked Immunosorbent Assay; Family medical history; Humans; Hypertension; Immunoglobulins - blood; Insulin; Internal Medicine; Male; Medical imaging; Medical sciences; Middle Aged; Multivariate analysis; Pathogenesis; Plasma; Proteins; Receptors, Cell Surface - blood; Severity of Illness Index; Tobacco; Tumor Necrosis Factor-alpha - blood
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.05.051

Association of Plasma F11 Receptor/Junctional Adhesion Molecule-A Levels With Human Atherosclerosis Erdal Cavusoglu, Elizabeth Kornecki, Malgorzata B. Sobocka, Anna Babinska, Yigal H. Ehrlich, Vineet Chopra, Sunitha Yanamadala, Cyril Ruwende, Moro O. Salifu, Luther T. Clark, Calvin Eng, David J. Pinsky, Jonathan D. Marmur The F11 receptor (F11R) is a molecule expressed on both platelets and the endothelium that is critical for platelet adhesion to a cytokine-inflamed endothelial surface. Using a novel enzyme-linked immunosorbent assay, plasma F11R levels were measured in 389 male patients undergoing coronary angiography. Plasma F11R levels were independently associated with the presence and severity of angiographically defined CAD. In addition, consistent with previously reported effects of tumor necrosis factor (TNF)-alpha on F11R expression in cultured endothelial cells, F11R levels correlated strongly with plasma TNF-alpha levels. Taken together, these findings suggest that F11R may be an important mediator of the effects of inflammation on the vessel wall. Strategies that block F11R may represent a novel approach to the treatment of human atherosclerosis.