Characterization of genuine and fake artesunate anti-malarial tablets using Fourier transform infrared imaging and spatially offset Raman spectroscopy through blister packs

In support of the efforts to combat the illegal sale and distribution of counterfeit anti-malarial drugs, we evaluated a new analytical approach for the characterization and fast screening of fake and genuine artesunate tablets using a combination of Raman spectroscopy, Spatially Offset Raman Spectr...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2007-11, Vol.389 (5), p.1525-1532
Main Authors: Ricci, Camilla, Eliasson, Charlotte, Macleod, Neil A, Newton, Paul N, Matousek, Pavel, Kazarian, Sergei G
Format: Article
Language:English
Subjects:
Antimalarials - analysis
Artemisinins - analysis
Artesunate
Chemical imaging
Fake drugs
FT-IR spectroscopy
malaria
Sesquiterpenes - analysis
SORS
Spectroscopy, Fourier Transform Infrared - methods
Spectrum Analysis, Raman - methods
Tablets - analysis
Turbid
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Summary:In support of the efforts to combat the illegal sale and distribution of counterfeit anti-malarial drugs, we evaluated a new analytical approach for the characterization and fast screening of fake and genuine artesunate tablets using a combination of Raman spectroscopy, Spatially Offset Raman Spectroscopy (SORS) and Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) imaging. Vibrational spectroscopy provided chemically specific information on the composition of the tablets; the complementary nature of Raman scattering and FTIR imaging allowed the characterization of both the overall and surface composition of the tablets. The depth-resolving power of the SORS approach provided chemically specific information on the overall composition of the tablets, non-invasively, through a variety of packaging types. Spatial imaging of the tablet surface (using ATR-FTIR) identified the location of domains of excipients and active ingredients with high sensitivity and enhanced spatial resolution. The advantages provided by a combination of SORS and ATR-FTIR imaging in this context confirm its potential for inclusion in the analytical protocol for forensic investigation of counterfeit medicines.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-007-1543-1