Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder

Children and adolescents with maltreatment‐related posttraumatic stress disorder (PTSD) exhibit smaller intracranial tissue volume than controls. Linear relationships have also been observed between intracranial tissue volume and the age of maltreatment onset. The authors explored associations among...

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Bibliographic Details
Published in:Journal of traumatic stress 2007-10, Vol.20 (5), p.763-774
Main Authors: Woodward, Steven H., Kaloupek, Danny G., Streeter, Chris C., Kimble, Matthew O., Reiss, Allan L., Eliez, Stephan, Wald, Lawrence L., Renshaw, Perry F., Frederick, Blaise B., Lane, Barton, Sheikh, Javaid I., Stegman, Wendy K., Kutter, Catherine J., Stewart, Lorraine P., Prestel, Rebecca S., Arsenault, Ned J.
Format: Article
Language:English
Subjects:
Adolescent
Brain - physiopathology
California
Cerebrospinal Fluid - metabolism
Child
Female
Gulf War
Humans
Magnetic Resonance Imaging
Male
Massachusetts
Skull - physiopathology
Stress Disorders, Post-Traumatic - physiopathology
Vietnam Conflict
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Summary:Children and adolescents with maltreatment‐related posttraumatic stress disorder (PTSD) exhibit smaller intracranial tissue volume than controls. Linear relationships have also been observed between intracranial tissue volume and the age of maltreatment onset. The authors explored associations among adult PTSD, early trauma, and cerebral volumes in 99 combat veterans. A bone‐based estimate of cranial volume was developed to adjust for variation in body size. Posttraumatic stress disorder was not associated with smaller cerebral tissue volume, but rather with smaller cerebrospinal fluid (CSF) and cranial volumes. These findings co‐occurred with expected effects of alcoholism and aging on cerebral tissue and CSF volumes. The results point to early developmental divergences between groups with and without PTSD following adult trauma.
ISSN:0894-9867
1573-6598
DOI:10.1002/jts.20241