Statin therapy is associated with improved outcomes in vascular surgery patients with renal impairment

• Published in: The American heart journal 2007-11, Vol.154 (5), p.954-961
• Main Authors: Welten, Gijs M.J.M., MD, Chonchol, Michel, MD, Hoeks, Sanne E., MSc, Schouten, Olaf, MD, Dunkelgrün, Martin, MD, van Gestel, Yvette R.B.M., MSc, Goei, Dustin, MD, Bax, Jeroen J., MD, van Domburg, Ron T., PhD, Poldermans, Don, MD, PhD
• Format: Article
• Language: English
• Subjects: Aged; Aortic Aneurysm, Abdominal - blood; Aortic Aneurysm, Abdominal - mortality; Aortic Aneurysm, Abdominal - surgery; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cause of Death; Cholesterol; Creatinine - blood; Drug therapy; Female; Follow-Up Studies; Heart attacks; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - drug therapy; Kidney Failure, Chronic - mortality; Male; Medical sciences; Middle Aged; Mortality; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Netherlands - epidemiology; Proportional Hazards Models; Renal failure; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Rate; Time Factors; Treatment Outcome; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels; Vascular Surgical Procedures - methods
• ISSN: 0002-8703; 1097-6744
• DOI: 10.1016/j.ahj.2007.06.040

Background Little is known about the association between baseline kidney function, statin therapy, and outcome after vascular surgery in patients with and without chronic kidney disease. Methods A total of 2126 patients underwent elective major vascular surgery and were divided into 2 categories based on baseline creatinine clearance (CrCl), calculated using the Cockcroft-Gault equation: CrCl ≥60 mL/min (n = 1358, reference) and CrCl