Level and Value of Interleukin-18 After Acute Ischemic Stroke

Background The prognostic value of the level of interleukin (IL)-18 in patients after acute ischemic stroke (IS) has not been completely investigated. This prospective cohort study examined whether the circulating IL-18 level can predict 90-day outcome of IS. Methods and Results Plasma IL-18 level w...

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Bibliographic Details
Published in:Circulation Journal 2007, Vol.71(11), pp.1691-1696
Main Authors: Yuen, Chun-Man, Chiu, Cheng-An, Chang, Li-Teh, Liou, Chia-Wei, Lu, Cheng-Hsien, Youssef, Ali A., Yip, Hon-Kan
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Brain Ischemia - blood
Case-Control Studies
Cohort Studies
Female
Humans
Inflammation - blood
Interleukin-18
Interleukin-18 - blood
Ischemic stroke
Major adverse clinical outcome
Male
Middle Aged
Predictive Value of Tests
Prognosis
Prospective Studies
Regression Analysis
Risk Factors
Stroke - blood
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Summary:Background The prognostic value of the level of interleukin (IL)-18 in patients after acute ischemic stroke (IS) has not been completely investigated. This prospective cohort study examined whether the circulating IL-18 level can predict 90-day outcome of IS. Methods and Results Plasma IL-18 level was obtained from blood samples taken by venous access at 48 h following acute IS in 217 consecutive patients. Plasma IL-18 level was also evaluated in 20 healthy and 40 at-risk control subjects. Plasma levels of IL-18 and white blood cell (WBC) counts were significantly higher in IS patients than in both control groups (all p values
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.71.1691