A Practical Overview of Aromatase Inhibitors

Tamoxifen has been the standard adjuvant therapy for patients with breast cancer for several decades. Various recently completed adjuvant trials using aromatase inhibitors have shown the superiority of these agents over Tamoxifen or placebo, when used in post-menopausal women. The results from these...

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Bibliographic Details
Published in:Anticancer research 2005-05, Vol.25 (3C), p.2497-2502
Main Authors: YOUNUS, Jawaid, VANDENBERG, Theodore A
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Aromatase Inhibitors - administration & dosage
Aromatase Inhibitors - therapeutic use
Biological and medical sciences
Breast Neoplasms - drug therapy
Chemotherapy, Adjuvant
Clinical Trials as Topic
Female
Humans
Medical sciences
Postmenopause
Tamoxifen - administration & dosage
Tamoxifen - therapeutic use
Tumors
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Summary:Tamoxifen has been the standard adjuvant therapy for patients with breast cancer for several decades. Various recently completed adjuvant trials using aromatase inhibitors have shown the superiority of these agents over Tamoxifen or placebo, when used in post-menopausal women. The results from these trials present a challenging situation for practicing oncologists with regards to the choice, duration, sequence of therapy, follow-up and side-effects of aromatase inhibitors. Various management issues from a practical angle for oncologists are discussed for the effective use of these agents, with an evidence-based approach.
ISSN:0250-7005
1791-7530