Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis

Abstract Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensivel...

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Bibliographic Details
Published in:Autoimmunity reviews 2007-11, Vol.7 (1), p.65-70
Main Authors: Cho, Young-Gyu, Cho, Mi-La, Min, So-Youn, Kim, Ho-Youn
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Arthritis, Experimental - immunology
Arthritis, Experimental - physiopathology
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - physiopathology
Autoantibodies - blood
Autoantigens - immunology
Autoimmunity
Cartilage - physiopathology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
Collagen Type II - immunology
Collagen Type II - metabolism
Collagen-induced arthritis (CIA)
Cytokines - immunology
Cytokines - metabolism
Dendritic Cells - immunology
Dendritic Cells - metabolism
Disease Models, Animal
IL-17
Inflammation Mediators - immunology
Inflammation Mediators - metabolism
Osteoclasts - physiology
Rheumatoid arthritis (RA)
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
Toll-like receptor (TLR)
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Summary:Abstract Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.
ISSN:1568-9972
1568-9972
DOI:10.1016/j.autrev.2007.08.001