Nuclear Area is a Prognostic Determinant in Advanced Colorectal Cancer

Background: The prognostic value of morphometric nuclear features in Dukes' Stages B/C and D colorectal cancer (CRC) was assessed. Patients and Methods: Primary tumours from 86 CRC patients were analysed, using an image overlay drawing system (Prodit Morphometry Program), for the following nucl...

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Bibliographic Details
Published in:Anticancer research 2005-07, Vol.25 (4), p.3083-3088
Main Authors: BUHMEIDA, Abdelbaset, RISTAMÄKI, Raija, LAMLUM, Hanan, BENDARDAF, Riyad, HEIKKILÄ, Suvi, COLLAN, Yrjö, SYRJÄNEN, Kari, PYRHÖNEN, Seppo
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Camptothecin - administration & dosage
Camptothecin - analogs & derivatives
Camptothecin - therapeutic use
Cell Nucleus - ultrastructure
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - pathology
Colorectal Neoplasms - ultrastructure
Female
Fluorouracil - administration & dosage
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Middle Aged
Neoplasm Staging
Prognosis
Proportional Hazards Models
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Rate
Tumors
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Summary:Background: The prognostic value of morphometric nuclear features in Dukes' Stages B/C and D colorectal cancer (CRC) was assessed. Patients and Methods: Primary tumours from 86 CRC patients were analysed, using an image overlay drawing system (Prodit Morphometry Program), for the following nuclear features: area, perimeter, diameter, form factor, roundness. Results: The median nuclear area (NA) was 104.6 μm 2 (range 57.2 - 237.2 μm 2 ). The NA was larger in patients with lymph node metastasis (p
ISSN:0250-7005
1791-7530