Elemental Tomography of Cancer-Cell Spheroids Reveals Incomplete Uptake of Both Platinum(II) and Platinum(IV) Complexes

The limited penetration of cytotoxic drugs into tumors is a significant contributing factor to the limited effectiveness of cancer chemotherapy. Here we have shown that X-ray fluorescence microtomography is a suitable technique for imaging the distribution of Pt drugs within multicellular tumor sphe...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Chemical Society 2007-11, Vol.129 (44), p.13400-13401
Main Authors: Alderden, Rebecca A, Mellor, Howard R, Modok, Szabolcs, Hall, Matthew D, Sutton, Stephen R, Newville, Matthew G, Callaghan, Richard, Hambley, Trevor W
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Cisplatin - chemistry
Cisplatin - pharmacokinetics
Humans
Microscopy, Fluorescence
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacokinetics
Platinum - chemistry
Sensitivity and Specificity
Spectrometry, X-Ray Emission - instrumentation
Spectrometry, X-Ray Emission - methods
Spheroids, Cellular - chemistry
Spheroids, Cellular - drug effects
Spheroids, Cellular - metabolism
Tissue Distribution
Tomography, X-Ray Computed - instrumentation
Tomography, X-Ray Computed - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The limited penetration of cytotoxic drugs into tumors is a significant contributing factor to the limited effectiveness of cancer chemotherapy. Here we have shown that X-ray fluorescence microtomography is a suitable technique for imaging the distribution of Pt drugs within multicellular tumor spheroids, models of solid tumors. This has revealed that there is no significant difference between the distributions of the range of Pt(II) and Pt(IV) complexes investigated, suggesting that complexes that are more resistant to cellular uptake may be needed to ensure more complete distribution throughout a tumor.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja076281t