Inflammation and coronary artery disease

Inflammation is now recognized as being pivotal in the pathogenesis of atherosclerosis. This review highlights key concepts in our current understanding of the role of inflammation in the initiation, progression, and complication of atherosclerosis. The role of various triggers and amplifiers and th...

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Bibliographic Details
Published in:The American heart journal 2005-07, Vol.150 (1), p.11-18
Main Authors: Tiong, Alice Y., Brieger, David
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Atherosclerosis
Biological and medical sciences
Biomarkers
Blood clots
Cardiology. Vascular system
Cardiovascular disease
Cell adhesion & migration
Chemokines
Collagen
Coronary Artery Disease - complications
Coronary Artery Disease - immunology
Coronary heart disease
Cytokines
Disease prevention
Disease Progression
Endothelium
Heart
Humans
Hypotheses
Immune system
Inflammation
Leukocytes
Lipids
Lipoproteins
Lymphocytes
Medical sciences
Muscular system
Smooth muscle
Thrombosis
Thrombosis - etiology
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Description
Summary:Inflammation is now recognized as being pivotal in the pathogenesis of atherosclerosis. This review highlights key concepts in our current understanding of the role of inflammation in the initiation, progression, and complication of atherosclerosis. The role of various triggers and amplifiers and the innate and adaptive immunity in the cascade of inflammatory events are also presented. Progress in our understanding of the inflammatory pathways in atherosclerosis has provided further mechanistic insight into the clinical benefits of current medical therapy and may alter our future treatment and preventive strategies.
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2004.12.019