Relation between insulin resistance and serum concentrations of IL-6 and TNF-α in overweight or obese women with early stage breast cancer

Insulin resistance (IR) and obesity may be risk factors for breast cancer. The mechanism of IR in patients with cancer has not been fully clarified yet. This study was conducted to evaluate the possible role of circulating cytokines; tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) in in...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2005-08, Vol.31 (4), p.264-269
Main Authors: Gonullu, Guzin, Ersoy, Canan, Ersoy, Alpaslan, Evrensel, Turkkan, Basturk, Bilkay, Kurt, Ender, Oral, Barboros, Gokgoz, Sehsuvar, Manavoglu, Osman
Format: Article
Language:English
Subjects:
Adult
Breast cancer
Breast Neoplasms - blood
Breast Neoplasms - complications
Case-Control Studies
Female
Humans
IL-6
Insulin Resistance
Interleukin-6 - blood
Middle Aged
Obesity
Obesity - blood
Obesity - complications
Prospective Studies
TNF-α
Tumor Necrosis Factor-alpha - metabolism
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Summary:Insulin resistance (IR) and obesity may be risk factors for breast cancer. The mechanism of IR in patients with cancer has not been fully clarified yet. This study was conducted to evaluate the possible role of circulating cytokines; tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) in inducing IR in 20 overweight or obese patients with early stage breast cancer and to compare their levels with that of body mass index matched 20 healthy controls. IR was calculated by homeostasis model assessment (HOMA) method. Four groups were formed according to a 2.7 HOMA-IR cut-off value as breast cancer with or without IR and controls with or without IR. IL-6 and HOMA-IR values were found to be higher in breast cancer patients with IR compared to other groups. There was no significant difference in TNF-α levels between groups. HOMA-IR values correlated with estradiol and IL-6 levels in all breast cancer patients but not TNF-α. HOMA-IR values, serum insulin, estradiol and IL-6 levels in the receptor positive group were significantly higher than those of the receptor negative group. These results suggested a possible contribution of endogenous IL-6 production and hyperinsulinemia to the development of breast cancer in overweight or obese patients with prominent IR.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2005.05.003