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Association of the 5,10-Methylenetetrahydrofolate Reductase (MTHFR C677T and A1298C) Polymorphisms in Korean Patients with Adult Acute Lymphoblastic Leukemia
Background: Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to methyl donor for DNA methylation. Because MTHFR is a key enzyme in folate metabolism, changes in its activity resulting from polymorphisms in the MTHFR gene could modify the susceptibility to cancer....
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Published in: | Anticancer research 2007-09, Vol.27 (5A), p.3419-3424 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Background: Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to methyl donor for DNA
methylation. Because MTHFR is a key enzyme in folate metabolism, changes in its activity resulting from polymorphisms in the
MTHFR gene could modify the susceptibility to cancer. Recently, the C677T and A1298C mutations of MTHFR were discovered to
be associated with susceptibility in acute lymphoblastic leukemia (ALL). Patients and Methods: The association between MTHFR
polymorphisms and susceptibility and clinical outcome in ALL was studied in 118 adult ALL patients and matched healthy controls
(n=427). DNA samples taken from patients with ALL and controls were analyzed using polymerase chain reaction-restriction fragment
length polymorphism (PCR-RFLP) assays to detect the MTHFR C677T and A1298C mutations. Results: No significant difference was
found in the development of adult ALL among those with different MTHFR genotypes of the C677T or A1298C polymorphisms. However,
the MTHFR 677CT+TT genotype showed a tendency to be associated with adult ALL [crude odds ratio (OR), 0.67; 95% confidence
interval (CI), 0.44-1.02; adjusted OR, 0.74 95% CI, 0.47-1.14]. Conclusion: The MTHFR C677T and A1298C polymorphisms are not
significant risk factors in adult acute leukemia in the Korean population. |
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ISSN: | 0250-7005 1791-7530 |