Proteomic Maps of the Cancer-Associated Infectious Agents

The number of infectious agents associated with cancer is increasing. There is a need to develop approaches for the early detection of the infected host which might lead to tumor development. Recent advances in proteomic approaches provide that opportunity, and it is now possible to generate proteom...

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Bibliographic Details
Published in:Journal of proteome research 2005-07, Vol.4 (4), p.1171-1180
Main Authors: Srivastava, Sudhir, Verma, Mukesh, Gopal-Srivastava, Rashmi
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor
Communicable Diseases - immunology
Humans
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - virology
Protein Array Analysis
Proteome - analysis
Viral Proteins - analysis
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Summary:The number of infectious agents associated with cancer is increasing. There is a need to develop approaches for the early detection of the infected host which might lead to tumor development. Recent advances in proteomic approaches provide that opportunity, and it is now possible to generate proteomic maps of cancer-associated infectious agents. Protein arrays, interaction maps, data archives, and biological assays are being developed to enable efficient and reliable protein identification and functional analysis. Herein, we discuss the current technologies and challenges in the field, and application of protein signatures in cancer detection and prevention. Keywords: acetylation • apoptosis • biomarkers • chromatin • early detection • epigenetics • epigenome • gene therapy • infectious agents • matrix-assisted laser capture ionization desorption mass spectrometry (MALDI MS) • methylation • post-translational modifications (PTM) • prevention • protein array • risk assessment • siRNA • vaccine • viral load
ISSN:1535-3893
1535-3907
DOI:10.1021/pr050017m