Cholestatic liver disease modulates susceptibility to ischemia/reperfusion-induced arrhythmia, but not necrosis and hemodynamic instability: The role of endogenous opioid peptides

Acute cholestasis is associated with cardiovascular complications, which mainly manifest during stressful conditions. The goal of this study is to evaluate susceptibility of 7-day bile duct-ligated rats to ischemia/reperfusion-induced injury. Sham-operated and cholestatic rats, treated with daily no...

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Bibliographic Details
Published in:Journal of hepatology 2005-09, Vol.43 (3), p.491-498
Main Authors: Hajrasouliha, Amir Reza, Tavakoli, Sina, Jabehdar-Maralani, Pejman, Ebrahimi, Farzad, Shafaroodi, Hamed, Mirkhani, Seyyed Hamid, Amanpour, Saied, Dehpour, Ahmad Reza
Format: Article
Language:English
Subjects:
Animals
Arrhythmia
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - physiopathology
Bile duct-ligation
Biological and medical sciences
Blood Pressure
Cardiac dysrhythmias
Cardiology. Vascular system
Cholestasis
Cholestasis, Intrahepatic - pathology
Cholestasis, Intrahepatic - physiopathology
Electrocardiography
Endogenous opioid peptides
Gastroenterology. Liver. Pancreas. Abdomen
Heart
Heart Rate
Hemodynamics
Ischemia/reperfusion
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Myocardial Infarction - pathology
Myocardial Infarction - physiopathology
Naltrexone - pharmacology
Necrosis
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide (NO)
Other diseases. Semiology
Rat
Rats
Rats, Sprague-Dawley
Reperfusion Injury - physiopathology
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Summary:Acute cholestasis is associated with cardiovascular complications, which mainly manifest during stressful conditions. The goal of this study is to evaluate susceptibility of 7-day bile duct-ligated rats to ischemia/reperfusion-induced injury. Sham-operated and cholestatic rats, treated with daily normal saline, L-NAME (a non-selective NO synthase inhibitor) naltrexone, or both L-NAME and naltrexone were subjected to 30 min of ischemia followed by 2 h of reperfusion. Cholestatic rats demonstrated significant bradycardia, hypotension ( P
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2005.02.043