Differential Expression of E‐Cadherin and Cytokeratin 19 and Net Proliferative Rate of Gingival Keratinocytes in Oral Epithelium in Periodontal Health and Disease

Background: The effects of periodontal disease on the oral gingival epithelium (OGE) have not been documented fully because they may not be as dramatic as those seen on the junctional epithelium. The aim of this study was to estimate the changes occurring in the OGE with respect to its proliferation...

Full description

Saved in:
Bibliographic Details
Published in:Journal of periodontology (1970) 2007-11, Vol.78 (11), p.2197-2202
Main Authors: Nagarakanti, S., Ramya, S., Babu, Praveen, Arun, K.V., Sudarsan, Sabitha
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Apoptosis
Biological and medical sciences
Cadherins - analysis
Cadherins - metabolism
Case-Control Studies
Cell Proliferation
Cytokeratin 19
Dentistry
Epithelium
E‐cadherin
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Genes, p53
gingiva
Gingiva - cytology
Humans
Keratin-19 - analysis
Keratin-19 - metabolism
Keratinocytes - cytology
Keratinocytes - metabolism
Ki-67 Antigen - analysis
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Periodontal Diseases - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: The effects of periodontal disease on the oral gingival epithelium (OGE) have not been documented fully because they may not be as dramatic as those seen on the junctional epithelium. The aim of this study was to estimate the changes occurring in the OGE with respect to its proliferation and E‐cadherin and cytokeratin 19 (K19) expression during pocket formation. Methods: Gingival samples were collected from 17 periodontally healthy subjects and 18 subjects with chronic periodontitis. K19 and E‐cadherin levels were analyzed immunohistochemically. The net proliferative rate was calculated as the difference between the proliferative rate and the apoptotic rate as determined by immunohistochemical analysis of Ki‐67 and p53, respectively. Results: There was a significant increase in the net proliferative rate of the OGE during pocket formation (periodontitis group, 220.90 ± 46.85; healthy group, 107.60 ± 25.86; P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2007.070070