Endobronchial adenosine monophosphate challenge causes tachykinin release in the human airway

Adenosine 5 monophosphate (AMP) has been shown to cause bronchoconstriction and a sensation of chest tightness when inhaled by asthmatic subjects. This response is attenuated after repeated inhalation of bradykinin, suggesting that AMP may act in part by the release of neuropeptides. This study exam...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2005-08, Vol.116 (2), p.312-317
Main Authors: Crummy, Fionnuala, Livingston, Mark, Ardill, Joy E.S., Adamson, Catherine, Ennis, Madeleine, Heaney, Liam G.
Format: Article
Language:English
Subjects:
Adenosine
Adenosine Monophosphate - pharmacology
Adult
Asthma
Biological and medical sciences
Bronchi - drug effects
Bronchi - secretion
Calcitonin Gene-Related Peptide - secretion
endobronchial challenge
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunopathology
Male
Medical sciences
Neurokinin A - secretion
neuropeptide
Neuropeptides
Substance P - secretion
Tachykinin
Tachykinins - secretion
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Summary:Adenosine 5 monophosphate (AMP) has been shown to cause bronchoconstriction and a sensation of chest tightness when inhaled by asthmatic subjects. This response is attenuated after repeated inhalation of bradykinin, suggesting that AMP may act in part by the release of neuropeptides. This study examined neuropeptide release in the human airway after endobronchial AMP challenge. Endobronchial AMP challenge was performed in 20 subjects and tachykinin levels were measured after endobronchial AMP challenge and after placebo endobronchial challenge with saline. All subjects coughed immediately after adenosine challenge. There was a significant increase in neurokinin A and substance P levels ( P
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2005.03.034