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Basic fibroblast growth factor reduces scar formation in acute incisional wounds
ABSTRACT In order to identify a means to reduce scar formation of the skin after incision, this study examined the effect of local administration of basic fibroblast growth factor (bFGF) in humans. bFGF was administered to a sutured wound immediately after an operation. The drug was injected once in...
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Published in: | Wound repair and regeneration 2007-09, Vol.15 (5), p.617-623 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | ABSTRACT
In order to identify a means to reduce scar formation of the skin after incision, this study examined the effect of local administration of basic fibroblast growth factor (bFGF) in humans. bFGF was administered to a sutured wound immediately after an operation. The drug was injected once into the dermis of the margins of wounds using a 27G needle or rinsing after performing dermostitches. The lengths of the treated wounds varied from 1 to 32 cm, and the subjects were 2–86 years old. Sutured wounds after excision of skin tumors from the face, trunk, and limbs and sutured wounds such as those at the donor sites of full‐thickness skin grafts were treated with low‐dose bFGF injections (0.1 μg/cm wound; Group 2), high‐dose bFGF injections (1 μg/cm wound; Group 3), and rinsed with high‐dose bFGF (1 μg/cm wound; Group 4). No patient treated with bFGF had hypertrophic scars, while some patients had hypertrophic or very wide scars in the control group (Group 1), and the ratios of minimum scarring of Group 2 ( p |
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ISSN: | 1067-1927 1524-475X |
DOI: | 10.1111/j.1524-475X.2007.00293.x |