B-Cells in Ocular Adnexal Lymphoproliferative Lesions Express B-cell attracting Chemokine 1 (CXCL13)

The homeostatic chemokine, B cell attracting chemokine 1 (CXCL13), has been implicated in the pathogenesis of lymphocyte-mediated diseases. We investigated the cellular expression of this chemokine in the spectrum of ocular adnexal lymphoproliferative lesions. Laboratory investigation. CXCL13 expres...

Full description

Saved in:
Bibliographic Details
Published in:American journal of ophthalmology 2005-08, Vol.140 (2), p.335-337
Main Authors: Falkenhagen, Katherine M., Braziel, Rita M., Fraunfelder, Frederick W., Smith, Justine R.
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Antigens, CD20 - metabolism
B-Lymphocytes - metabolism
Biological and medical sciences
Biopsy
Cell adhesion & migration
Chemokine CXCL13
Chemokines
Chemokines, CXC - metabolism
Conjunctival Diseases - metabolism
Conjunctival Diseases - pathology
Conjunctival Neoplasms - metabolism
Conjunctival Neoplasms - pathology
Hematologic and hematopoietic diseases
Humans
Immune system
Immunohistochemistry
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocytes
Lymphoma, B-Cell - metabolism
Lymphoma, B-Cell - pathology
Medical sciences
Miscellaneous
Ophthalmology
Pseudolymphoma - metabolism
Pseudolymphoma - pathology
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The homeostatic chemokine, B cell attracting chemokine 1 (CXCL13), has been implicated in the pathogenesis of lymphocyte-mediated diseases. We investigated the cellular expression of this chemokine in the spectrum of ocular adnexal lymphoproliferative lesions. Laboratory investigation. CXCL13 expression in paraffin-embedded adnexal biopsy specimens was determined by indirect immunohistochemistry with antigen retrieval. In 15 of 16 biopsy specimens, including reactive lymphoid hyperplasia (n = 7), atypical lymphoid hyperplasia (n = 3), and B cell lymphoma (n = 6), CXCL13 was detected. CD20-positive B-cells, as well as dendritic cells and endothelial cells, expressed the chemokine. B-cells in ocular adnexal lymphoproliferative lesions demonstrate expression of CXCL13, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2005.02.026