Collectin surfactant protein D binds antibodies and interlinks innate and adaptive immune systems

Innate immune collectins, such as surfactant protein D (SP-D), contain fibrillar collagen-like regions and globular carbohydrate-recognition domains (CRDs). SP-D recognizes carbohydrate arrays present on microbial surfaces via its CRDs, agglutinates microbes and enhances their phagocytosis. In contr...

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Bibliographic Details
Published in:FEBS letters 2005-08, Vol.579 (20), p.4449-4453
Main Authors: Nadesalingam, Jeya, Reid, Kenneth B.M., Palaniyar, Nades
Format: Article
Language:English
Subjects:
Adaptive immunity
Animals
Antibody recognition
carbohydrate-recognition domain
Collectins
CRD
ELISA
enzyme-linked immunosorbant assay
Humans
Immune system evolution
Immunity, Innate
Immunoglobulin Fab Fragments - immunology
Immunoglobulin Fc Fragments - immunology
Immunoglobulins - immunology
Innate immunity
mannose-binding lectin
MBL
Mice
Phagocytosis - drug effects
Pulmonary Surfactant-Associated Protein D - drug effects
Pulmonary Surfactant-Associated Protein D - immunology
Pulmonary Surfactant-Associated Protein D - physiology
surfactant protein
Surfactant protein D
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Summary:Innate immune collectins, such as surfactant protein D (SP-D), contain fibrillar collagen-like regions and globular carbohydrate-recognition domains (CRDs). SP-D recognizes carbohydrate arrays present on microbial surfaces via its CRDs, agglutinates microbes and enhances their phagocytosis. In contrast, adaptive immune proteins such as immunoglobulins (Igs) recognize pathogens via binding to specific antigens. Here we show that: SP-D binds various classes of immunoglobins, including IgG, IgM, IgE and secretory IgA, but not serum IgA; the globular domains of SP-D bind both the Fab and Fc domains of IgG; SP-D recognizes IgG via calcium-dependent protein–protein interactions, aggregates IgG-coated beads and enhances their phagocytosis by murine macrophage RAW 264.7 cells. Therefore, we propose that SP-D effectively interlinks innate and adaptive immune systems.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2005.07.012