Prognostic Value of Different Metabolic Measurements with Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography in Resectable Non-Small Cell Lung Cancer: A Two-Center Study

• Published in: Journal of thoracic oncology 2007-11, Vol.2 (11), p.1007-1012
• Main Authors: de Jong, Wouter K., van der Heijden, Henricus F.M., Pruim, Jan, Dalesio, Otilia, Oyen, Wim J.G., Groen, Harry J.M.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Carcinoma, Non-Small-Cell Lung - diagnostic imaging; Carcinoma, Non-Small-Cell Lung - metabolism; Disease Progression; Disease-Free Survival; Female; Fluorine-18 fluorodeoxyglucose positron emission tomography; Fluorodeoxyglucose F18; Humans; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - therapy; Lymphatic Metastasis; Male; Middle Aged; Non-small cell lung cancer; Positron-Emission Tomography - methods; Prognosis; Radiopharmaceuticals - metabolism; Standard uptake value; Survival Rate
• ISSN: 1556-0864; 1556-1380
• DOI: 10.1097/JTO.0b013e31815608f5

Standard uptake value (SUV) is a quantitative measure for the preferential uptake of a radiopharmaceutical in a tumor compared with the homogeneous distribution in the body. SUV can be based on the maximal value of one pixel (SUVmax) or on the mean value in a region outlined by isodensity contours. The prognostic value of different SUVs in non-small cell lung cancer (NSCLC) is not established. We evaluated this value for SUVmax, SUV70%, and SUV50% among patients with resectable NSCLC. All consecutive patients with resectable NSCLC who underwent an attenuation-corrected whole-body fluorine-18 fluorodeoxyglucose positron emission tomography scan from two university hospitals were selected. By adjusting the isocontour in the region of interest on the scan, SUVmax, SUV70%, and SUV50% of the primary tumor were calculated. Sixty-six patients (50 male, median age 63 years) were included. Of the tumors, 16 were pathological stage IA, 23 were IB, 4 were IIA, 14 were IIB, and 9 were IIIA. Median (range) values for SUVmax, SUV70%, and SUV50% were 6.4 (1.6–19.1), 5.1 (1.0–15.7), and 4.0 (0.9–13.4), respectively. SUVs were associated with survival. Analysis of residuals of SUVmax as a continuous variable in a Cox's proportional hazard model for survival suggested no cutoff point and no indication of time-dependency. Patients with a SUV higher than the median value had a worse survival than patients with a SUV lower than median (hazard ratios for SUVmax, SUV70%, and SUV50% all were 2.9; p = 0.02). SUVmax, SUV70%, and SUV50% measured with fluorine-18 fluorodeoxyglucose positron emission tomography have a similar prognostic value, and no “natural― cutoff point for SUVmax in resectable NSCLC was identified.