The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease

The human endogenous retroviruses HERV-K113 and HERV-K115 are full-length proviruses but unusual in being found in only a proportion of the population. Here, we study the geographic distribution of these HERVs and their prevalence in autoimmune disease. The frequency of HERV-K113 and HERV-K115 in 17...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2005-09, Vol.86 (3), p.337-341
Main Authors: Moyes, David L., Martin, Alex, Sawcer, Stephen, Temperton, Nigel, Worthington, Jane, Griffiths, David J., Venables, Patrick J.
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - virology
Autoimmune disease
Autoimmune Diseases - virology
Biological and medical sciences
Endogenous retrovirus
Endogenous Retroviruses - genetics
Endogenous Retroviruses - isolation & purification
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genes. Genome
Genetics of eukaryotes. Biological and molecular evolution
HERV
Humans
Medical sciences
Molecular and cellular biology
Molecular genetics
Multiple sclerosis
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sjögren's syndrome
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Summary:The human endogenous retroviruses HERV-K113 and HERV-K115 are full-length proviruses but unusual in being found in only a proportion of the population. Here, we study the geographic distribution of these HERVs and their prevalence in autoimmune disease. The frequency of HERV-K113 and HERV-K115 in 174 individuals from Africa was 21.8 and 34.1%, respectively, compared to 4.16 and 1% in 96 people in the United Kingdom ( p 
ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2005.06.004