A Note on the Antitubercular Activities of 1-Aryl-5-benzylsulfanyltetrazoles

A set of 32 1‐phenyl‐5‐benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis. The activity against M. tuberculosis becomes higher with increasing...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 2005-08, Vol.338 (8), p.385-389
Main Authors: Adamec, Jan, Waisser, Karel, Kuneš, Jiří, Kaustová, Jarmila
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antitubercular Agents - chemical synthesis
Antitubercular Agents - chemistry
Antitubercular Agents - pharmacology
Benzylsulfanyltetrazoles
Biological and medical sciences
Medical sciences
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Pharmacology. Drug treatments
Phase-transfer catalysis
Structure-Activity Relationship
Tetrazoles - chemical synthesis
Tetrazoles - chemistry
Tetrazoles - pharmacology
Tuberculostatics
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Summary:A set of 32 1‐phenyl‐5‐benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis. The activity against M. tuberculosis becomes higher with increasing electron‐accepting properties of the substituents on the phenyl ring. On the other hand, any substitution on the benzylic moiety decreases the activity.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.200400967