DNA methyltransferases and structural-functional specificity of eukaryotic DNA modification

Properties of the main families of mammalian, plant, and fungal DNA methyltransferases are considered. Structural-functional specificity of eukaryotic genome sequences methylated by DNA methyltransferases is characterized. The total methylation of cytosine in DNA sequences is described, as well as i...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2005-07, Vol.70 (7), p.730-742
Main Authors: Buryanov, Ya I, Shevchuk, T V
Format: Article
Language:English
Subjects:
Animals
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA - genetics
DNA - metabolism
DNA methylation
DNA Modification Methylases - chemistry
DNA Modification Methylases - genetics
DNA Modification Methylases - metabolism
Eukaryotes
Eukaryotic Cells - metabolism
Gene Expression Regulation, Enzymologic
Humans
Methylation
Methyltransferases
Proteins
Sensitivity and Specificity
Sequence Analysis, DNA
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Summary:Properties of the main families of mammalian, plant, and fungal DNA methyltransferases are considered. Structural-functional specificity of eukaryotic genome sequences methylated by DNA methyltransferases is characterized. The total methylation of cytosine in DNA sequences is described, as well as its relation with RNA interference. Mechanisms of regulation of expression and modulation of DNA methyltransferase activity in the eukaryotic cell are discussed.
ISSN:0006-2979
1608-3040
0320-9725
DOI:10.1007/s10541-005-0178-0