A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population

Association analysis, based on linkage disequilibrium between specific alleles in the candidate loci and nearby genetic markers, has been proposed to identify genes conferring susceptibility to multifactorial diseases. Using the affected sib-pair method, we previously mapped four candidate chromosom...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2005-09, Vol.335 (2), p.566-574
Main Authors: Aoki, Masayuki, Yamamoto, Ken, Ohyama, Shigekazu, Yamamura, Yoshitaka, Takenoshita, Seiichi, Sugano, Kokichi, Minamoto, Toshinari, Kitajima, Masaki, Sugimura, Haruhiko, Shimada, Shinya, Noshiro, Hirokazu, Hiratsuka, Masahiro, Sairenji, Motonori, Ninomiya, Itasu, Yano, Masahiko, Uesaka, Katsuhiko, Matsuno, Seiki, Maehara, Yoshihiko, Aikou, Takashi, Sasazuki, Takehiko
Format: Article
Language:English
Subjects:
Alleles
Association study
Case-Control Studies
Chromosome 21q
Gastric cancer
Gene Expression Regulation, Neoplastic
Genetic Markers
Genetic Predisposition to Disease
Genetic Variation
Genotype
Haplotypes
HSP70 Heat-Shock Proteins - genetics
Humans
Japan
Linkage disequilibrium
Molecular Chaperones - genetics
Odds Ratio
Oligonucleotide Array Sequence Analysis
Polymorphism
Polymorphism, Genetic
Polymorphism, Single Nucleotide - genetics
Single nucleotide polymorphism
STCH
Stomach Neoplasms - genetics
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Summary:Association analysis, based on linkage disequilibrium between specific alleles in the candidate loci and nearby genetic markers, has been proposed to identify genes conferring susceptibility to multifactorial diseases. Using the affected sib-pair method, we previously mapped four candidate chromosomal regions, 1p32, 2q33–q35, 11p13–p14, and 21q21, for gastric cancer by linkage analysis. To identify genes involved in the disease, we performed a gene-based association analysis of 66 genes, located on 21p11–21q22, using 126 single nucleotide polymorphisms (SNPs) as genetic markers in 373 patients with 250 controls. We found a significant association of five SNPs in the stress70 protein chaperon family member STCH gene with gastric cancer, especially with the non-cardia localization subgroup ( P = 0.0005–0.02, odds ratio = 1.44–1.72). Comparisons of haplotype frequency showed significant association between TTGGC haplotype and gastric cancer ( P = 0.0001, odds ratio = 1.59). These results suggest that, in the Japanese population, STCH might be a new candidate for conferring susceptibility to this disease.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2005.07.110