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The role of hepatitis E virus testing in drug‐induced liver injury
Summary Background Locally acquired hepatitis E is an emerging infection in developed countries and can be misdiagnosed as drug‐induced liver injury. Aim To study the role of hepatitis E virus (HEV) testing in drug‐induced liver injury. Methods Retrospective review of a cohort of patients with su...
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| Published in: | Alimentary Pharmacology and Therapeutics 2007-11, Vol.26 (10), p.1429-1435 |
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| container_title | Alimentary Pharmacology and Therapeutics |
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| creator | DALTON, H. R. FELLOWS, H. J. STABLEFORTH, W. JOSEPH, M. THURAIRAJAH, P. H. WARSHOW, U. HAZELDINE, S. REMNARACE, R. IJAZ, S. HUSSAINI, S. H. BENDALL, R. P. |
| description | Summary
Background Locally acquired hepatitis E is an emerging infection in developed countries and can be misdiagnosed as drug‐induced liver injury.
Aim To study the role of hepatitis E virus (HEV) testing in drug‐induced liver injury.
Methods Retrospective review of a cohort of patients with suspected drug‐induced liver injury (n = 69) and hepatitis E (n = 45). The standard criteria for drug‐induced liver injury were applied. Patients with suspected drug‐induced liver injury who met these criteria were retrospectively tested for HEV on stored sera taken at the time of presentation. The two cohorts were compared to determine variables that predicted either of the diagnoses.
Results Forty‐seven out of 69 patients had criterion‐referenced drug‐induced liver injury. 22/47 were HEV negative and thus had confirmed drug‐induced liver injury. 19/47 were not tested for HEV, as there was no sera available from the time of presentation. 6/47 were HEV positive and thus did not have drug‐induced liver injury, but had hepatitis E infection. Compared to patients with confirmed drug‐induced liver injury, patients with hepatitis E were significantly more likely to be male (OR 3.09, CI 1.05–9.08); less likely to present in November and December (0.03, CI 0.01–0.52); have lower serum bilirubin (P = 0.015); and higher serum alanine aminotransferase (P |
| doi_str_mv | 10.1111/j.1365-2036.2007.03504.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68475060</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68475060</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5444-6faa3efce72ccbace8b0bf85e9444cacd0cc43a49bc7ef0c40d6130e638810983</originalsourceid><addsrcrecordid>eNqNkEtOwzAQhi0EgvK4AvIGdgkTO3GcBQvEW0KCRVlbjjMBV2lS7KbQHUfgjJwEh1awBG9seb6Z-fURQhOIk3BOJnHCRRYx4CJmAHkMPIM0ftsgo5_CJhkBE0XEZMJ3yK73EwAQObBtspPkMvAMRuRi_IzUdQ3SrqbPONNzO7eeXtKFdb2nc_Rz2z5R29LK9U-f7x-2rXqDFW3sAl34n_RuuU-2at14PFjfe-Tx6nJ8fhPd3V_fnp_dRSZL0zQStdYca4M5M6bUBmUJZS0zLELVaFOBMSnXaVGaHGswKVQi4YCCS5lAIfkeOV7NnbnupQ_R1NR6g02jW-x6r4RM8wwE_AkyyCHjLAugXIHGdd47rNXM2al2S5WAGlSriRqMqsGoGlSrb9XqLbQernf05RSr38a12wAcrQHtjW5qp1tj_S9XZAJyLgJ3uuJebYPLfwdQZw_j4cW_ACxEmpA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20705325</pqid></control><display><type>article</type><title>The role of hepatitis E virus testing in drug‐induced liver injury</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>DALTON, H. R. ; FELLOWS, H. J. ; STABLEFORTH, W. ; JOSEPH, M. ; THURAIRAJAH, P. H. ; WARSHOW, U. ; HAZELDINE, S. ; REMNARACE, R. ; IJAZ, S. ; HUSSAINI, S. H. ; BENDALL, R. P.</creator><creatorcontrib>DALTON, H. R. ; FELLOWS, H. J. ; STABLEFORTH, W. ; JOSEPH, M. ; THURAIRAJAH, P. H. ; WARSHOW, U. ; HAZELDINE, S. ; REMNARACE, R. ; IJAZ, S. ; HUSSAINI, S. H. ; BENDALL, R. P.</creatorcontrib><description>Summary
Background Locally acquired hepatitis E is an emerging infection in developed countries and can be misdiagnosed as drug‐induced liver injury.
Aim To study the role of hepatitis E virus (HEV) testing in drug‐induced liver injury.
Methods Retrospective review of a cohort of patients with suspected drug‐induced liver injury (n = 69) and hepatitis E (n = 45). The standard criteria for drug‐induced liver injury were applied. Patients with suspected drug‐induced liver injury who met these criteria were retrospectively tested for HEV on stored sera taken at the time of presentation. The two cohorts were compared to determine variables that predicted either of the diagnoses.
Results Forty‐seven out of 69 patients had criterion‐referenced drug‐induced liver injury. 22/47 were HEV negative and thus had confirmed drug‐induced liver injury. 19/47 were not tested for HEV, as there was no sera available from the time of presentation. 6/47 were HEV positive and thus did not have drug‐induced liver injury, but had hepatitis E infection. Compared to patients with confirmed drug‐induced liver injury, patients with hepatitis E were significantly more likely to be male (OR 3.09, CI 1.05–9.08); less likely to present in November and December (0.03, CI 0.01–0.52); have lower serum bilirubin (P = 0.015); and higher serum alanine aminotransferase (P < 0.001) and alanine aminotransferase/alkaline phosphatase ratio (P < 0.001).
Conclusion The diagnosis of drug‐induced liver injury is not secure without testing for HEV.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>EISSN: 0953-0673</identifier><identifier>DOI: 10.1111/j.1365-2036.2007.03504.x</identifier><identifier>PMID: 17850420</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Biological and medical sciences ; Case-Control Studies ; Cohort Studies ; Diagnostic Errors - prevention & control ; Digestive system ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis E - diagnosis ; Hepatitis E virus ; Hepatitis E virus - isolation & purification ; Humans ; Liver - virology ; Liver Diseases - diagnosis ; Liver Diseases - virology ; Liver Function Tests - methods ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments</subject><ispartof>Alimentary Pharmacology and Therapeutics, 2007-11, Vol.26 (10), p.1429-1435</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5444-6faa3efce72ccbace8b0bf85e9444cacd0cc43a49bc7ef0c40d6130e638810983</citedby><cites>FETCH-LOGICAL-c5444-6faa3efce72ccbace8b0bf85e9444cacd0cc43a49bc7ef0c40d6130e638810983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19560736$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17850420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DALTON, H. R.</creatorcontrib><creatorcontrib>FELLOWS, H. J.</creatorcontrib><creatorcontrib>STABLEFORTH, W.</creatorcontrib><creatorcontrib>JOSEPH, M.</creatorcontrib><creatorcontrib>THURAIRAJAH, P. H.</creatorcontrib><creatorcontrib>WARSHOW, U.</creatorcontrib><creatorcontrib>HAZELDINE, S.</creatorcontrib><creatorcontrib>REMNARACE, R.</creatorcontrib><creatorcontrib>IJAZ, S.</creatorcontrib><creatorcontrib>HUSSAINI, S. H.</creatorcontrib><creatorcontrib>BENDALL, R. P.</creatorcontrib><title>The role of hepatitis E virus testing in drug‐induced liver injury</title><title>Alimentary Pharmacology and Therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background Locally acquired hepatitis E is an emerging infection in developed countries and can be misdiagnosed as drug‐induced liver injury.
Aim To study the role of hepatitis E virus (HEV) testing in drug‐induced liver injury.
Methods Retrospective review of a cohort of patients with suspected drug‐induced liver injury (n = 69) and hepatitis E (n = 45). The standard criteria for drug‐induced liver injury were applied. Patients with suspected drug‐induced liver injury who met these criteria were retrospectively tested for HEV on stored sera taken at the time of presentation. The two cohorts were compared to determine variables that predicted either of the diagnoses.
Results Forty‐seven out of 69 patients had criterion‐referenced drug‐induced liver injury. 22/47 were HEV negative and thus had confirmed drug‐induced liver injury. 19/47 were not tested for HEV, as there was no sera available from the time of presentation. 6/47 were HEV positive and thus did not have drug‐induced liver injury, but had hepatitis E infection. Compared to patients with confirmed drug‐induced liver injury, patients with hepatitis E were significantly more likely to be male (OR 3.09, CI 1.05–9.08); less likely to present in November and December (0.03, CI 0.01–0.52); have lower serum bilirubin (P = 0.015); and higher serum alanine aminotransferase (P < 0.001) and alanine aminotransferase/alkaline phosphatase ratio (P < 0.001).
Conclusion The diagnosis of drug‐induced liver injury is not secure without testing for HEV.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Diagnostic Errors - prevention & control</subject><subject>Digestive system</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis E - diagnosis</subject><subject>Hepatitis E virus</subject><subject>Hepatitis E virus - isolation & purification</subject><subject>Humans</subject><subject>Liver - virology</subject><subject>Liver Diseases - diagnosis</subject><subject>Liver Diseases - virology</subject><subject>Liver Function Tests - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><issn>0269-2813</issn><issn>1365-2036</issn><issn>0953-0673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkEtOwzAQhi0EgvK4AvIGdgkTO3GcBQvEW0KCRVlbjjMBV2lS7KbQHUfgjJwEh1awBG9seb6Z-fURQhOIk3BOJnHCRRYx4CJmAHkMPIM0ftsgo5_CJhkBE0XEZMJ3yK73EwAQObBtspPkMvAMRuRi_IzUdQ3SrqbPONNzO7eeXtKFdb2nc_Rz2z5R29LK9U-f7x-2rXqDFW3sAl34n_RuuU-2at14PFjfe-Tx6nJ8fhPd3V_fnp_dRSZL0zQStdYca4M5M6bUBmUJZS0zLELVaFOBMSnXaVGaHGswKVQi4YCCS5lAIfkeOV7NnbnupQ_R1NR6g02jW-x6r4RM8wwE_AkyyCHjLAugXIHGdd47rNXM2al2S5WAGlSriRqMqsGoGlSrb9XqLbQernf05RSr38a12wAcrQHtjW5qp1tj_S9XZAJyLgJ3uuJebYPLfwdQZw_j4cW_ACxEmpA</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>DALTON, H. R.</creator><creator>FELLOWS, H. J.</creator><creator>STABLEFORTH, W.</creator><creator>JOSEPH, M.</creator><creator>THURAIRAJAH, P. H.</creator><creator>WARSHOW, U.</creator><creator>HAZELDINE, S.</creator><creator>REMNARACE, R.</creator><creator>IJAZ, S.</creator><creator>HUSSAINI, S. H.</creator><creator>BENDALL, R. P.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200711</creationdate><title>The role of hepatitis E virus testing in drug‐induced liver injury</title><author>DALTON, H. R. ; FELLOWS, H. J. ; STABLEFORTH, W. ; JOSEPH, M. ; THURAIRAJAH, P. H. ; WARSHOW, U. ; HAZELDINE, S. ; REMNARACE, R. ; IJAZ, S. ; HUSSAINI, S. H. ; BENDALL, R. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5444-6faa3efce72ccbace8b0bf85e9444cacd0cc43a49bc7ef0c40d6130e638810983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Diagnostic Errors - prevention & control</topic><topic>Digestive system</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis E - diagnosis</topic><topic>Hepatitis E virus</topic><topic>Hepatitis E virus - isolation & purification</topic><topic>Humans</topic><topic>Liver - virology</topic><topic>Liver Diseases - diagnosis</topic><topic>Liver Diseases - virology</topic><topic>Liver Function Tests - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DALTON, H. R.</creatorcontrib><creatorcontrib>FELLOWS, H. J.</creatorcontrib><creatorcontrib>STABLEFORTH, W.</creatorcontrib><creatorcontrib>JOSEPH, M.</creatorcontrib><creatorcontrib>THURAIRAJAH, P. H.</creatorcontrib><creatorcontrib>WARSHOW, U.</creatorcontrib><creatorcontrib>HAZELDINE, S.</creatorcontrib><creatorcontrib>REMNARACE, R.</creatorcontrib><creatorcontrib>IJAZ, S.</creatorcontrib><creatorcontrib>HUSSAINI, S. H.</creatorcontrib><creatorcontrib>BENDALL, R. P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary Pharmacology and Therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DALTON, H. R.</au><au>FELLOWS, H. J.</au><au>STABLEFORTH, W.</au><au>JOSEPH, M.</au><au>THURAIRAJAH, P. H.</au><au>WARSHOW, U.</au><au>HAZELDINE, S.</au><au>REMNARACE, R.</au><au>IJAZ, S.</au><au>HUSSAINI, S. H.</au><au>BENDALL, R. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of hepatitis E virus testing in drug‐induced liver injury</atitle><jtitle>Alimentary Pharmacology and Therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2007-11</date><risdate>2007</risdate><volume>26</volume><issue>10</issue><spage>1429</spage><epage>1435</epage><pages>1429-1435</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><eissn>0953-0673</eissn><abstract>Summary
Background Locally acquired hepatitis E is an emerging infection in developed countries and can be misdiagnosed as drug‐induced liver injury.
Aim To study the role of hepatitis E virus (HEV) testing in drug‐induced liver injury.
Methods Retrospective review of a cohort of patients with suspected drug‐induced liver injury (n = 69) and hepatitis E (n = 45). The standard criteria for drug‐induced liver injury were applied. Patients with suspected drug‐induced liver injury who met these criteria were retrospectively tested for HEV on stored sera taken at the time of presentation. The two cohorts were compared to determine variables that predicted either of the diagnoses.
Results Forty‐seven out of 69 patients had criterion‐referenced drug‐induced liver injury. 22/47 were HEV negative and thus had confirmed drug‐induced liver injury. 19/47 were not tested for HEV, as there was no sera available from the time of presentation. 6/47 were HEV positive and thus did not have drug‐induced liver injury, but had hepatitis E infection. Compared to patients with confirmed drug‐induced liver injury, patients with hepatitis E were significantly more likely to be male (OR 3.09, CI 1.05–9.08); less likely to present in November and December (0.03, CI 0.01–0.52); have lower serum bilirubin (P = 0.015); and higher serum alanine aminotransferase (P < 0.001) and alanine aminotransferase/alkaline phosphatase ratio (P < 0.001).
Conclusion The diagnosis of drug‐induced liver injury is not secure without testing for HEV.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17850420</pmid><doi>10.1111/j.1365-2036.2007.03504.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Alimentary Pharmacology and Therapeutics, 2007-11, Vol.26 (10), p.1429-1435 |
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| subjects | Aged Biological and medical sciences Case-Control Studies Cohort Studies Diagnostic Errors - prevention & control Digestive system Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis E - diagnosis Hepatitis E virus Hepatitis E virus - isolation & purification Humans Liver - virology Liver Diseases - diagnosis Liver Diseases - virology Liver Function Tests - methods Male Medical sciences Middle Aged Pharmacology. Drug treatments |
| title | The role of hepatitis E virus testing in drug‐induced liver injury |
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