Matrigel: Basement membrane matrix with biological activity

The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function. An extract of a tumor was found to contain all of the components present in base...

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Bibliographic Details
Published in:Seminars in cancer biology 2005-10, Vol.15 (5), p.378-386
Main Authors: Kleinman, Hynda K., Martin, George R.
Format: Article
Language:English
Subjects:
Animals
Aorta - pathology
Basement membrane
Basement Membrane - metabolism
Basement Membrane - pathology
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Cell Culture Techniques
Cell Differentiation
Cell Line, Tumor
Cell Survival
Collagen - chemistry
Collagen - metabolism
Collagen - pharmacology
Culture Media - pharmacology
Differentiation
Drug Combinations
Endothelium, Vascular - cytology
Endothelium, Vascular - metabolism
Extracellular matrix
Extracellular Matrix - metabolism
Fibroblasts - metabolism
Humans
Laminin
Laminin - chemistry
Laminin - metabolism
Laminin - pharmacology
Matrigel
Neoplasms - metabolism
Neovascularization, Pathologic
Proteoglycans - chemistry
Proteoglycans - metabolism
Proteoglycans - pharmacology
Salivary Glands - pathology
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Summary:The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function. An extract of a tumor was found to contain all of the components present in basement and to be very biologically active. This extract, termed Matrigel, Cultrex, or EHS matrix, promotes cell differentiation, and is used to measure the invasive activity of tumor cells. In vivo, it is used for measuring angiogenic inhibitors and stimulators, to improve graft survival, repair damaged tissues, and increase tumor growth.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2005.05.004