TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1

Toll‐like receptors (TLR) have a key role in regulating immunity against microbial agents. Engagement of TLR by bacterial, viral or fungal components leads to the production and release of inflammatory cytokines. In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human...

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Bibliographic Details
Published in:European journal of immunology 2005-08, Vol.35 (8), p.2416-2423
Main Authors: Triantafilou, Kathy, Vakakis, Emmanouil, Orthopoulos, George, Ahmed, Mohamed Abd Elrahman, Schumann, Christian, Lepper, Philipp M., Triantafilou, Martha
Format: Article
Language:English
Subjects:
Adult
Cell Line
Cell Line, Tumor
Cells, Cultured
Cytokines - metabolism
endosomes
Endosomes - metabolism
HPEV1
Humans
Male
Membrane Glycoproteins - physiology
Parechovirus - genetics
Parechovirus - immunology
Picornaviridae Infections - immunology
Picornaviridae Infections - metabolism
Receptors, Cell Surface - physiology
Respiratory Mucosa - immunology
Respiratory Mucosa - metabolism
Respiratory Mucosa - virology
RNA, Viral - physiology
Signal Transduction - immunology
TLR
TLR7
TLR8
Toll-Like Receptor 7
Toll-Like Receptor 8
Toll-Like Receptors
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Summary:Toll‐like receptors (TLR) have a key role in regulating immunity against microbial agents. Engagement of TLR by bacterial, viral or fungal components leads to the production and release of inflammatory cytokines. In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single‐stranded RNA (ssRNA) virus. Furthermore, we see that the viral ssRNA genome is detected in endosomal compartments by these TLR, which activate signalling that lead to the synthesis of pro‐inflammatory molecules by the host.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.200526149