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Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH)
X-box-binding protein 1 (XBP-1) is a basic-region leucine zipper protein in the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors involved in different cell-differentiation processes. We have investigated the expression of XBP-1 in...
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| Published in: | Cell biology international 2005-08, Vol.29 (8), p.647-653 |
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| Main Authors: | , , , , , |
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| container_end_page | 653 |
| container_issue | 8 |
| container_start_page | 647 |
| container_title | Cell biology international |
| container_volume | 29 |
| creator | Zambelli, A. Mongiardini, E. Villegas, S.N. Carri, N.G. Boot-Handford, R.P. Wallis, G.A. |
| description | X-box-binding protein 1 (XBP-1) is a basic-region leucine zipper protein in the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors involved in different cell-differentiation processes. We have investigated the expression of XBP-1 in differentiating MC3T3-E1 osteoblastic cells. Cultures were treated with ascorbic acid (AA) and β-glycerophosphate (BGP) to induce differentiation. Under these conditions, the basal transcription of
xbp-1 increases at day 2 following induction, peaks at day 5 and decreases thereafter. This result showed that
xbp-1 gene is differentially expressed during MC3T3-E1 cell differentiation. Detection of XBP-1 by immunofluorescence at days 0 (control culture without AA and BGP), 8 and 21 showed that the protein has a major cytoplasmic perinuclear location. In addition,
xbp-1 is transcriptionally upregulated by parathyroid hormone within 2.5
h of treatment and decreases thereafter. |
| doi_str_mv | 10.1016/j.cellbi.2005.03.018 |
| format | article |
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xbp-1 increases at day 2 following induction, peaks at day 5 and decreases thereafter. This result showed that
xbp-1 gene is differentially expressed during MC3T3-E1 cell differentiation. Detection of XBP-1 by immunofluorescence at days 0 (control culture without AA and BGP), 8 and 21 showed that the protein has a major cytoplasmic perinuclear location. In addition,
xbp-1 is transcriptionally upregulated by parathyroid hormone within 2.5
h of treatment and decreases thereafter.</description><identifier>ISSN: 1065-6995</identifier><identifier>EISSN: 1095-8355</identifier><identifier>DOI: 10.1016/j.cellbi.2005.03.018</identifier><identifier>PMID: 15936220</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Animals ; Ascorbic Acid - pharmacology ; Blotting, Northern ; Cell Differentiation - drug effects ; Cell Nucleus - metabolism ; Cytoplasm - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Fluorescent Antibody Technique ; Gene Expression Regulation - drug effects ; Glycerophosphates - pharmacology ; Mice ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Osteoblast differentiation ; Osteoblasts - cytology ; Osteoblasts - metabolism ; Parathyroid Hormone - pharmacology ; PTH ; Regulatory Factor X Transcription Factors ; RNA, Messenger - analysis ; Trans-Activators ; Transcription Factors ; X-Box Binding Protein 1 ; XBP-1</subject><ispartof>Cell biology international, 2005-08, Vol.29 (8), p.647-653</ispartof><rights>2005 International Federation for Cell Biology</rights><rights>The Author(s) Journal compilation © 2005 International Federation for Cell Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4952-20896d1ef63b1358119c44ac1ea880aaa5d580dc8a4fcbe7f6c2d6cbd66aabc93</citedby><cites>FETCH-LOGICAL-c4952-20896d1ef63b1358119c44ac1ea880aaa5d580dc8a4fcbe7f6c2d6cbd66aabc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15936220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zambelli, A.</creatorcontrib><creatorcontrib>Mongiardini, E.</creatorcontrib><creatorcontrib>Villegas, S.N.</creatorcontrib><creatorcontrib>Carri, N.G.</creatorcontrib><creatorcontrib>Boot-Handford, R.P.</creatorcontrib><creatorcontrib>Wallis, G.A.</creatorcontrib><title>Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH)</title><title>Cell biology international</title><addtitle>Cell Biol Int</addtitle><description>X-box-binding protein 1 (XBP-1) is a basic-region leucine zipper protein in the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors involved in different cell-differentiation processes. We have investigated the expression of XBP-1 in differentiating MC3T3-E1 osteoblastic cells. Cultures were treated with ascorbic acid (AA) and β-glycerophosphate (BGP) to induce differentiation. Under these conditions, the basal transcription of
xbp-1 increases at day 2 following induction, peaks at day 5 and decreases thereafter. This result showed that
xbp-1 gene is differentially expressed during MC3T3-E1 cell differentiation. Detection of XBP-1 by immunofluorescence at days 0 (control culture without AA and BGP), 8 and 21 showed that the protein has a major cytoplasmic perinuclear location. In addition,
xbp-1 is transcriptionally upregulated by parathyroid hormone within 2.5
h of treatment and decreases thereafter.</description><subject>Animals</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Blotting, Northern</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Nucleus - metabolism</subject><subject>Cytoplasm - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Fluorescent Antibody Technique</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glycerophosphates - pharmacology</subject><subject>Mice</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Osteoblast differentiation</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - metabolism</subject><subject>Parathyroid Hormone - pharmacology</subject><subject>PTH</subject><subject>Regulatory Factor X Transcription Factors</subject><subject>RNA, Messenger - analysis</subject><subject>Trans-Activators</subject><subject>Transcription Factors</subject><subject>X-Box Binding Protein 1</subject><subject>XBP-1</subject><issn>1065-6995</issn><issn>1095-8355</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhSMEoqXwBgh5hWCRYCex47BAoqNOW1GVCg0_O-vGvmk9ZOJgJ6V5BN6ahIyAFWLlu_i-I_mcKHrKaMIoE6-2icamqWySUsoTmiWUyXvRIaMlj2XG-f35FjwWZckPokchbCllLJfiYXTAeJmJNKWH0Y-NhzZob7veupbUoHvnyZfjq5gRGwjedR5DQEPM4G17TVzo0VUNhJ4YW9fose0t_HKhNbPS_x0ITTMSj9dDA_0UUo2kAw_9zeidNeTG-Z1rkby42py9fBw9qKEJ-GT_HkUf1yeb1Vl88f70fPX2ItZ5ydM4pbIUhmEtsoplXDJW6jwHzRCkpADADZfUaAl5rSssaqFTI3RlhACodJkdRc-X3M67bwOGXu1smKuEFt0QlJB5IURKJzBfQO1dCB5r1Xm7Az8qRtU8gdqqZQI1T6BopqYJJu3ZPn-odmj-SPvOJ-D1Any3DY7_FapWx-eXTBTpJMeLbKch7n7L4L8qUWQFV58vT1X5SX5Ys2Kt3k38m4XHqdJbi14FbbHVaKxH3Svj7L-_8xOJab52</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Zambelli, A.</creator><creator>Mongiardini, E.</creator><creator>Villegas, S.N.</creator><creator>Carri, N.G.</creator><creator>Boot-Handford, R.P.</creator><creator>Wallis, G.A.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200508</creationdate><title>Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH)</title><author>Zambelli, A. ; Mongiardini, E. ; Villegas, S.N. ; Carri, N.G. ; Boot-Handford, R.P. ; Wallis, G.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4952-20896d1ef63b1358119c44ac1ea880aaa5d580dc8a4fcbe7f6c2d6cbd66aabc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Blotting, Northern</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Nucleus - metabolism</topic><topic>Cytoplasm - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Fluorescent Antibody Technique</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glycerophosphates - pharmacology</topic><topic>Mice</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Osteoblast differentiation</topic><topic>Osteoblasts - cytology</topic><topic>Osteoblasts - metabolism</topic><topic>Parathyroid Hormone - pharmacology</topic><topic>PTH</topic><topic>Regulatory Factor X Transcription Factors</topic><topic>RNA, Messenger - analysis</topic><topic>Trans-Activators</topic><topic>Transcription Factors</topic><topic>X-Box Binding Protein 1</topic><topic>XBP-1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zambelli, A.</creatorcontrib><creatorcontrib>Mongiardini, E.</creatorcontrib><creatorcontrib>Villegas, S.N.</creatorcontrib><creatorcontrib>Carri, N.G.</creatorcontrib><creatorcontrib>Boot-Handford, R.P.</creatorcontrib><creatorcontrib>Wallis, G.A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell biology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zambelli, A.</au><au>Mongiardini, E.</au><au>Villegas, S.N.</au><au>Carri, N.G.</au><au>Boot-Handford, R.P.</au><au>Wallis, G.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH)</atitle><jtitle>Cell biology international</jtitle><addtitle>Cell Biol Int</addtitle><date>2005-08</date><risdate>2005</risdate><volume>29</volume><issue>8</issue><spage>647</spage><epage>653</epage><pages>647-653</pages><issn>1065-6995</issn><eissn>1095-8355</eissn><abstract>X-box-binding protein 1 (XBP-1) is a basic-region leucine zipper protein in the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors involved in different cell-differentiation processes. We have investigated the expression of XBP-1 in differentiating MC3T3-E1 osteoblastic cells. Cultures were treated with ascorbic acid (AA) and β-glycerophosphate (BGP) to induce differentiation. Under these conditions, the basal transcription of
xbp-1 increases at day 2 following induction, peaks at day 5 and decreases thereafter. This result showed that
xbp-1 gene is differentially expressed during MC3T3-E1 cell differentiation. Detection of XBP-1 by immunofluorescence at days 0 (control culture without AA and BGP), 8 and 21 showed that the protein has a major cytoplasmic perinuclear location. In addition,
xbp-1 is transcriptionally upregulated by parathyroid hormone within 2.5
h of treatment and decreases thereafter.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>15936220</pmid><doi>10.1016/j.cellbi.2005.03.018</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell biology international, 2005-08, Vol.29 (8), p.647-653 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animals Ascorbic Acid - pharmacology Blotting, Northern Cell Differentiation - drug effects Cell Nucleus - metabolism Cytoplasm - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fluorescent Antibody Technique Gene Expression Regulation - drug effects Glycerophosphates - pharmacology Mice Nuclear Proteins - genetics Nuclear Proteins - metabolism Osteoblast differentiation Osteoblasts - cytology Osteoblasts - metabolism Parathyroid Hormone - pharmacology PTH Regulatory Factor X Transcription Factors RNA, Messenger - analysis Trans-Activators Transcription Factors X-Box Binding Protein 1 XBP-1 |
| title | Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH) |
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