The fibrinogen gamma (FGG) 10034C>T polymorphism is associated with venous thrombosis

• Published in: Thrombosis research 2007, Vol.121 (1), p.33-36
• Main Authors: Grünbacher, Gerda, Weger, Wolfgang, Marx-Neuhold, Ernestine, Pilger, Ernst, Köppel, Herwig, Wascher, Thomas, März, Winfried, Renner, Wilfried
• Format: Article
• Language: English
• Subjects: Adult; Aged; Atherosclerosis (general aspects, experimental research); Austria - epidemiology; Biological and medical sciences; Blood and lymphatic vessels; Blood. Blood coagulation. Reticuloendothelial system; Cardiology. Vascular system; Case-Control Studies; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; DNA Mutational Analysis; Female; Fibrinogen; Fibrinogen - genetics; Genetic Predisposition to Disease; Genotype; Hematology, Oncology and Palliative Medicine; Humans; Male; Medical sciences; Middle Aged; Multivariate Analysis; Odds Ratio; Pharmacology. Drug treatments; Polymorphism; Polymorphism, Single Nucleotide; Risk factor; Risk Factors; Thrombosis; Venous Thrombosis - genetics
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2007.03.007

Abstract Introduction Thrombin-induced conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in the stabilization of thrombi. Elevated plasma fibrinogen levels have been associated with both increased plasma viscosity and platelet aggregability. Recently, a haplotype-tagging single nucleotide polymorphism characterized by a C to T substitution at nucleotide 10034 of the fibrinogen gamma gene (FGG 10034C>T, rs2066865), has been proposed as a novel risk factor for deep venous thrombosis (DVT). Aim of the present study was to provide further data on the role of the FGG 10034C>T polymorphism for DVT. Materials and methods FGG genotypes were determined by 5′-exonuclease assay (TaqMan) in 358 patients with documented DVT and a total of 783 control subjects. Results In a multivariate analysis adjusting for age, sex, presence of factor V Leiden and carriage of prothrombin 20210A, homozygosity for the FGG 10034 TT genotype yielded an odds ratio of 2.01 (95% CI 1.23–3.31; p = 0.006) for DVT. Conclusions Our data confirm the primary finding that the FGG 10034C>T polymorphism is associated with DVT risk.