Role of Cytokine Polymorphisms in the Risk of Distal Gastric Cancer Development

We review the current information concerning the role of cytokine polymorphisms and the risk of develop distal gastric cancer in different populations. We have included populations colonized with Helicobacter pylori as well as populations without colonization. We found that the study of polymorphism...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2005-08, Vol.14 (8), p.1869-1873
Main Authors: Guillermo I. Perez-Perez, Elvira Garza-Gonzalez, Cynthia Portal, Asalia Z. Olivares
Format: Article
Language:English
Subjects:
Case-Control Studies
Cytokine
cytokines
Female
Gastrointestinal cancers: stomach
Genetics, Population
Genotype
Helicobacter pylori
Helicobacter pylori - genetics
Helicobacter pylori - immunology
Helicobacter pylori - pathogenicity
Humans
Interleukin-1 - genetics
Male
polymorphisms
Risk Factors
Stomach Neoplasms - genetics
Stomach Neoplasms - microbiology
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - physiology
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Summary:We review the current information concerning the role of cytokine polymorphisms and the risk of develop distal gastric cancer in different populations. We have included populations colonized with Helicobacter pylori as well as populations without colonization. We found that the study of polymorphisms alone seems insufficient to assess gastric cancer risk and it is necessary to examine environmental factors in different ethnic groups and geographic areas along with the study of H. pylori strains to define better the risk factors associated with distal gastric cancer.
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-04-0889