Successful Analysis of Anticancer Drug Sensitivity by CD-DST Using Pleural Fluid and Ascites from Patients with Advanced Ovarian Cancer: Case Reports

In vitro anticancer drug sensitivity tests have been performed for various types of cancers, and a relationship with clinical response has been observed. The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) is a new in vitro anticancer drug sensitivity test by Yabushita et al., r...

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Bibliographic Details
Published in:Anticancer research 2005-09, Vol.25 (5), p.3547-3551
Main Authors: KAWAGUCHI, Makiko, BANNO, Kouji, SUSUMU, Nobuyuki, YANOKURA, Megumi, KUWABARA, Yoshiko, HIRAO, Nobumaru, TSUKAZAKI, Katsumi, NOZAWA, Shiro
Format: Article
Language:English
Subjects:
Abdomen
Antineoplastic Combined Chemotherapy Protocols - pharmacology
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Ascites - pathology
Biological and medical sciences
Camptothecin - administration & dosage
Camptothecin - analogs & derivatives
Camptothecin - pharmacology
Cisplatin - administration & dosage
Cisplatin - pharmacology
Doxorubicin - administration & dosage
Doxorubicin - pharmacology
Drug Screening Assays, Antitumor - methods
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Medical sciences
Middle Aged
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - pathology
Other diseases. Semiology
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - pathology
Paclitaxel - administration & dosage
Paclitaxel - pharmacology
Pleural Effusion, Malignant - pathology
Taxoids - administration & dosage
Taxoids - pharmacology
Tumors
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Summary:In vitro anticancer drug sensitivity tests have been performed for various types of cancers, and a relationship with clinical response has been observed. The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) is a new in vitro anticancer drug sensitivity test by Yabushita et al., recently reported to be useful in ovarian cancer. CD-DST allows analysis of a small number of cells, compared to other anticancer drug sensitivity tests. Here, we report a successful analysis of anticancer drug sensitivity by CD-DST using cancerous ascites and pleural fluid samples from 2 patients with advanced ovarian cancer. To our knowledge, this is only the second report of the application of CD-DST in ovarian cancer, and our results suggest that CD-DST could be helpful in the selection of anticancer drugs for neoadjuvant chemotherapy in advanced ovarian cancer.
ISSN:0250-7005
1791-7530