Successful outcome of severe adenovirus hepatitis of the allograft following liver transplantation

: Here we report the first adult patient who survived severe adenoviral hepatitis of a liver graft, in contrast to 4 previously reported cases in adults, all of which had a fatal outcome. Early diagnosis was based on the immunohistological detection of adenoviral protein in the context of biopsy‐pro...

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Published in:Transplant infectious disease 2007-12, Vol.9 (4), p.318-322
Main Authors: Perez, D., McCormack, L., Petrowsky, H., Jochum, W., Mullhaupt, B., Clavien, P.‐A.
Format: Article
Language:English
Subjects:
Adenovirus
Adenovirus Infections, Human - diagnosis
Adenovirus Infections, Human - drug therapy
Adenovirus Infections, Human - virology
Adult
allograft
hepatitis
Hepatitis, Viral, Human - diagnosis
Hepatitis, Viral, Human - drug therapy
Hepatitis, Viral, Human - virology
Humans
Immunocompromised Host
Liver - virology
liver transplantation
Liver Transplantation - adverse effects
Male
Prednisone - administration & dosage
Transplantation, Homologous
Transplants - virology
Treatment Outcome
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Summary:: Here we report the first adult patient who survived severe adenoviral hepatitis of a liver graft, in contrast to 4 previously reported cases in adults, all of which had a fatal outcome. Early diagnosis was based on the immunohistological detection of adenoviral protein in the context of biopsy‐proven hepatitis. Dramatic reduction of immunosuppression along with supportive care were the treatment strategies in this case. Adenoviral infection of the allograft should always be considered as a differential diagnosis when clinical signs of severe hepatitis are present after liver transplantation. Accurate diagnosis with immunohistochemical detection of viral proteins in the liver graft is of paramount importance for the early diagnosis and management of this uncommon, severe, and probably underdiagnosed entity.
ISSN:1398-2273
1399-3062
DOI:10.1111/j.1399-3062.2007.00205.x