Apoer2: A Reelin Receptor to Remember

The extracellular protein Reelin is crucial for neuronal positioning during brain development, but its expression persists long after cell migration is completed. In this issue of Neuron, Beffert et al. demonstrate that Reelin exerts an additional function in the mature brain, to modulate synaptic p...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2005-08, Vol.47 (4), p.471-473
Main Author: D’Arcangelo, Gabriella
Format: Article
Language:English
Subjects:
Alternative Splicing - physiology
Animals
Behavior
Brain
Brain - metabolism
Cell Adhesion Molecules, Neuronal - metabolism
Extracellular Matrix Proteins - metabolism
Gene expression
Humans
Kinases
LDL-Receptor Related Proteins
Low density lipoprotein receptors
Memory
Migration
Nerve Tissue Proteins - metabolism
Neuronal Plasticity - physiology
Phosphorylation
Protein Binding - physiology
Proteins
Receptors, Lipoprotein - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Rodents
Schizophrenia
Serine Endopeptidases - metabolism
Signal transduction
Studies
Synapses - metabolism
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Description
Summary:The extracellular protein Reelin is crucial for neuronal positioning during brain development, but its expression persists long after cell migration is completed. In this issue of Neuron, Beffert et al. demonstrate that Reelin exerts an additional function in the mature brain, to modulate synaptic plasticity and to favor memory formation. This activity is carried out exquisitely by the Apoer2 receptor and critically requires the presence of an alternatively spliced exon. This exon encodes an intracellular domain that interacts with postsynaptic proteins and promotes binding and phosphorylation of NMDA receptors.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2005.08.001