Pre-transplant level of soluble CD30 is associated with infection after heart transplantation

: Background:  One immunologic element of the immune system is the CD30 molecule which belongs to the TNF‐R superfamily. CD30 can serve as a T‐cell signal transducing molecule and is expressed by a subset of activated T lymphocytes, CD45RO+ memory T cells. Augmentation of soluble CD30 during kidney...

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Bibliographic Details
Published in:Clinical transplantation 2007-11, Vol.21 (6), p.744-747
Main Authors: Nikaein, Afzal, Spiridon, Camelia, Hunt, Judson, Rosenthal, Jed, Anderson, Allan, Eichhorn, Erick, Magee, Mitchell, Dewey, Todd, Mack, Michael
Format: Article
Language:English
Subjects:
Biological and medical sciences
CD30 Ligand - blood
Enzyme-Linked Immunosorbent Assay
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection - blood
Graft Rejection - etiology
Graft Rejection - immunology
Heart Transplantation
Humans
Immunity, Cellular - immunology
immunology
Incidence
Infection - blood
Infection - complications
Infection - immunology
Medical sciences
Prognosis
soluble CD30
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
T-Lymphocytes - immunology
Texas - epidemiology
Tissue, organ and graft immunology
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Summary:: Background:  One immunologic element of the immune system is the CD30 molecule which belongs to the TNF‐R superfamily. CD30 can serve as a T‐cell signal transducing molecule and is expressed by a subset of activated T lymphocytes, CD45RO+ memory T cells. Augmentation of soluble CD30 during kidney transplant (Tx) rejection has been reported. Our study was to determine if the level of sCD30 prior to heart transplant (HTx) could categorize the patients (pts) into high or low immunologic risk for post‐Tx outcome. Methods:  Pre‐Tx sera from 100 consecutive HTx recipients were studied. sCD30 was detected by ELISA using the commercially available CD30 monoclonal antibody. Level of sCD30 was correlated with two‐yr Tx outcome. Results:  Significant correlation was seen between the high level of sCD30 and lower incidence of infection. Four of the 35 pts with pre‐Tx high level of sCD30 level (>90 U/mL) developed infection post‐Tx. However, 31/65 pts who had a low level of sCD30 (
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2007.00732.x