Suppression of cell‐mediated immunity by a donor‐transmitted lymphocytic choriomeningitis virus in a kidney transplant recipient

: Infection with lymphocytic choriomeningitis virus (LCMV) in rodents, the primary host, is known to cause suppression of cell‐mediated immunity. Serial determinations using a functional cell‐mediated immune assay in a kidney transplant recipient with donor‐transmitted LCMV also suggested profound s...

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Bibliographic Details
Published in:Transplant infectious disease 2007-12, Vol.9 (4), p.339-342
Main Authors: Gautam, Amitabh, Fischer, S.A., Yango, A.F., Gohh, R.Y., Morrissey, P.E., Monaco, A.P.
Format: Article
Language:English
Subjects:
CD4‐positive T lymphocytes
cellular immunity
Female
Humans
Immunity, Cellular - immunology
immunologic monitoring
Immunosuppression
Kidney - virology
kidney transplantation
Kidney Transplantation - adverse effects
Lymphocytic Choriomeningitis - immunology
Lymphocytic Choriomeningitis - pathology
Lymphocytic choriomeningitis virus
Lymphocytic choriomeningitis virus - immunology
Male
Middle Aged
Tissue Donors
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Summary:: Infection with lymphocytic choriomeningitis virus (LCMV) in rodents, the primary host, is known to cause suppression of cell‐mediated immunity. Serial determinations using a functional cell‐mediated immune assay in a kidney transplant recipient with donor‐transmitted LCMV also suggested profound suppression of cellular immunity. This suppression persisted in spite of reduction of immunosuppression. With the clearance of the virus there was reconstitution of the cellular immune response.
ISSN:1398-2273
1399-3062
DOI:10.1111/j.1399-3062.2007.00232.x