Immune response to Saccharomyces cerevisiae mannan conjugate in mice

Mannan, the surface polysaccharide antigen of Saccharomyces cerevisiae was partially oxidized and conjugated to a protein carrier. Prepared conjugate was immunogenic in mice and re-injection elicited significant increase of anti- S. cerevisiae specific IgG and IgM serum antibodies. There was somewha...

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Bibliographic Details
Published in:International immunopharmacology 2005-11, Vol.5 (12), p.1693-1698
Main Authors: PAULOVICOVA, Ema, BYSTRICKY, Slavomir, MASAROVA, Jana, MACHOVA, Eva, MISLOVICOVA, Danica
Format: Article
Language:English
Subjects:
Animals
Antibodies, Fungal - blood
Antibodies, Fungal - immunology
Biological and medical sciences
Female
IgG serum antibodies
Immunization
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M - blood
Immunoglobulin M - immunology
Mannan conjugate
Mannans - immunology
Mannans - isolation & purification
Medical sciences
Mice
Mice, Inbred ICR
Pharmacology. Drug treatments
Saccharomyces cerevisiae
Saccharomyces cerevisiae - immunology
Saccharomyces cerevisiae - metabolism
Vaccines, Conjugate - immunology
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Summary:Mannan, the surface polysaccharide antigen of Saccharomyces cerevisiae was partially oxidized and conjugated to a protein carrier. Prepared conjugate was immunogenic in mice and re-injection elicited significant increase of anti- S. cerevisiae specific IgG and IgM serum antibodies. There was somewhat less increase in IgM serum antibodies. Serum distribution of IgG subclasses, especially IgG 2(a + b) : IgG 1 ratio throughout the immunization demonstrated effective Th1 predominance of immune response. Newly synthesized S. cerevisiae mannan conjugate could be considered as a perspective vaccine candidate for preventive immunomodulation treatment.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2005.04.009