Comparison of Diagnostic Accuracy of 64-Slice Computed Tomography Coronary Angiography in Women Versus Men With Angina Pectoris

• Published in: The American journal of cardiology 2007-11, Vol.100 (10), p.1532-1537
• Main Authors: Meijboom, W. Bob, MD, Weustink, Annick C., MD, Pugliese, Francesca, MD, van Mieghem, Carlos A.G., MD, Mollet, Nico R., MD, PhD, van Pelt, Niels, MD, Cademartiri, Filippo, MD, PhD, Nieman, Koen, MD, PhD, Vourvouri, Eleni, MD, PhD, Regar, Eveline, MD, PhD, Krestin, Gabriel P., MD, PhD, de Feyter, Pim J., MD, PhD
• Format: Article
• Language: English
• Subjects: Accuracy; Angina Pectoris - complications; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cardiovascular system; Coronary Angiography - methods; Coronary Artery Disease - diagnosis; Coronary heart disease; Coronary Stenosis - diagnosis; Female; Heart; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical imaging; Medical sciences; Middle Aged; Predictive Value of Tests; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Sensitivity and Specificity; Severity of Illness Index; Sex Factors; Tomography, X-Ray Computed - methods
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2007.06.061

We compared the diagnostic accuracy of 64-slice computed tomographic (CT) coronary angiography to detect significant coronary artery disease (CAD) in women and men. The 64-slice CT coronary angiography was performed in 402 symptomatic patients, 123 women and 279 men, with CAD prevalence of 51% and 68%, respectively. Significant CAD, defined as ≥50% coronary stenosis on quantitative coronary angiography, was evaluated on a patient, vessel, and segment level. The sensitivity and negative predictive value to detect significant CAD was very good, both for women and men (100% vs 99%, p = NS; 100% vs 98%, p = NS), whereas diagnostic accuracy (88% vs 96%; p