Bronchodilatory effects of the aqueous extract of Gynostemma pentaphyllum and gypenosides III and VIII in anaesthetized guinea-pigs

The bronchodilatory activity of the aqueous extract of Gynostemma pentaphyllum Makino leaves was investigated in anaesthetized guinea‐pigs and compared with two of its isolated gypenosides (III and VIII). The results showed that the intravenous administration of the decoction of G. pentaphyllum (2.5...

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Bibliographic Details
Published in:Journal of pharmacy and pharmacology 2005-08, Vol.57 (8), p.1053-1057
Main Authors: Circosta, Clara, de Pasquale, Rita, Palumbo, Dora R., Occhiuto, Francesco
Format: Article
Language:English
Subjects:
Animals
Antigens
Bronchoconstriction - drug effects
Bronchoconstriction - immunology
Bronchodilator Agents - administration & dosage
Bronchodilator Agents - pharmacology
Guinea Pigs
Gynostemma - chemistry
Histamine
Male
Oleaceae - immunology
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Leaves - chemistry
Respiratory System - drug effects
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Summary:The bronchodilatory activity of the aqueous extract of Gynostemma pentaphyllum Makino leaves was investigated in anaesthetized guinea‐pigs and compared with two of its isolated gypenosides (III and VIII). The results showed that the intravenous administration of the decoction of G. pentaphyllum (2.5, 5 or 10 mg kg−1) decreased bronchial resistance in basal conditions and significantly (P
ISSN:0022-3573
2042-7158
DOI:10.1211/0022357056613