A Case-Control Study to Examine HLA Haplotype Associations in Patients with Posttreatment Chronic Lyme Disease

In a comparison of 95 patients with systemic symptoms that persisted after antibiotic treatment for acute Lyme disease (posttreatment chronic Lyme disease) and 104 control subjects without such symptoms after antibiotic treatment, we sought associations between human leukocyte antigen class II (DRB1...

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Bibliographic Details
Published in:The Journal of infectious diseases 2005-09, Vol.192 (6), p.1010-1013
Main Authors: Klempner, Mark S., Wormser, Gary H., Wade, Karen, Trevino, Richard P., Tang, Jianming, Kaslow, Richard A., Schmid, Christopher
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Antibiotics
Bacteria
Blood
Borrelia burgdorferi
Case-Control Studies
Disease models
Female
Gene frequency
Genetic Predisposition to Disease
Haplotypes
HLA antigens
HLA-DQ Antigens - genetics
HLA-DQ beta-Chains
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Infections
Lyme disease
Lyme Disease - complications
Lyme Disease - drug therapy
Lyme Disease - genetics
Male
Middle Aged
Symptoms
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Summary:In a comparison of 95 patients with systemic symptoms that persisted after antibiotic treatment for acute Lyme disease (posttreatment chronic Lyme disease) and 104 control subjects without such symptoms after antibiotic treatment, we sought associations between human leukocyte antigen class II (DRB1 and DQB1) markers and posttreatment chronic Lyme disease. No strong association between posttreatment chronic Lyme disease and any class II allele or genotype was found
ISSN:0022-1899
1537-6613
DOI:10.1086/432733