Antecedent hypoglycaemia attenuates vascular endothelial growth factor response to subsequent hypoglycaemia in healthy men

Aim  The plasma concentration of vascular endothelial growth factor (VEGF) has recently been shown to increase sharply in response to hypoglycaemia and, thus, has been proposed as having a role in hypoglycaemia counter‐regulation. Many counter‐regulatory hormones show a reduced response after antece...

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Bibliographic Details
Published in:Diabetic medicine 2005-09, Vol.22 (9), p.1278-1281
Main Authors: Merl, V., Peters, A., Oltmanns, K. M., Kern, W., Hubold, C., Fehm, H. L., Born, J., Schultes, B.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Glucose - analysis
blood-brain barrier
Cognition
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Epinephrine - blood
Etiopathogenesis. Screening. Investigations. Target tissue resistance
glucose transport
Humans
Hypoglycemia - blood
Male
Medical sciences
Memory, Short-Term
recurrent hypoglycaemia
vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
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Summary:Aim  The plasma concentration of vascular endothelial growth factor (VEGF) has recently been shown to increase sharply in response to hypoglycaemia and, thus, has been proposed as having a role in hypoglycaemia counter‐regulation. Many counter‐regulatory hormones show a reduced response after antecedent hypoglycaemia. We therefore investigated whether this decrease in responsiveness with repetitive hypoglycaemia also pertains to VEGF. Methods  Three hypoglycaemic clamp experiments were performed on two consecutive days in 15 healthy men. VEGF response was assessed during the first and last hypoglycaemic period. Results  As expected, plasma VEGF concentrations rose markedly during the clamps (P 
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2005.01590.x