A novel chromosomal abnormality, t(6;10)(q27;q22), found in a polycythemic potential donor for allogeneic hematopoietic stem cell transplantation

A 59-year-old man was a potential donor for allogeneic hematopoietic stem cell transplantation and was found to be healthy but slightly polycythemic. The bone marrow was morphologically normal, but karyotyping of bone marrow cells showed t(6;10)(q27;q22) in 7 of 20 metaphases analyzed by G-banding a...

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Bibliographic Details
Published in:International journal of hematology 2005-07, Vol.82 (1), p.72-74
Main Authors: MITSUI, Hideki, SAITO, Norimitsu, SATAKE, Atsushi, NAKAZAWA, Tsuyoshi, KARASUNO, Takahiro, HIRAOKA, Akira
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 6
Diseases of red blood cells
Donor Selection
Hematologic and hematopoietic diseases
Hematopoietic Stem Cell Transplantation
Humans
Karyotyping
Medical sciences
Middle Aged
Polycythemia - genetics
Polycythemias
Tissue Donors
Translocation, Genetic
Transplantation, Homologous
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Summary:A 59-year-old man was a potential donor for allogeneic hematopoietic stem cell transplantation and was found to be healthy but slightly polycythemic. The bone marrow was morphologically normal, but karyotyping of bone marrow cells showed t(6;10)(q27;q22) in 7 of 20 metaphases analyzed by G-banding and only the t(6;10) abnormality in 3 of 5 metaphases analyzed by the spectral karyotyping method. G-banding analysis of peripheral blood mononuclear cells cultured with phytohemagglutinin for 72 hours showed a normal karyotype in all 20 metaphases analyzed.These findings suggest clonal expansion with t(6;10)(q27;q22) in the bone marrow of this individual. He was determined to be ineligible for donation. A coordinated nationwide work-up for older donors is necessary to ensure high-quality standards.
ISSN:0925-5710
1865-3774
DOI:10.1532/IJH97.05027