Results of alcohol and albendazole injections in hepatic hydatidosis: Experimental study

• Published in: Journal of gastroenterology and hepatology 2005-09, Vol.20 (9), p.1442-1447
• Main Authors: YETIM, IBRAHIM, ERZURUMLU, KENAN, HOKELEK, MURAT, BARIS, SANCAR, DERVISOGLU, ADEM, POLAT, CAFER, BELET, UMIT, BUYUKKARABACAK, YALÇIN, GUVENLI, ABDULLAH
• Format: Article
• Language: English
• Subjects: albendazole; Albendazole - administration & dosage; alcohol; Animals; Anti-Infective Agents, Local - administration & dosage; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Biliary Tract - drug effects; Biological and medical sciences; Diseases caused by cestodes; Drainage; Echinococcoses; Echinococcosis, Hepatic - drug therapy; Echinococcosis, Hepatic - surgery; Ethanol - administration & dosage; Helminthic diseases; hydatid cyst; Infectious diseases; Injections, Intralesional; Medical sciences; Parasitic diseases; percutaneous drainage; Pharmacology. Drug treatments; Rabbits; Solutions - administration & dosage
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/j.1440-1746.2005.03843.x

Background:  Percutaneous drainage with alcohol injection for hydatid cysts has been commonly used in the last two decades. Albendazole is the drug of choice in the medical treatment of hydatidosis, and has also been used as an intraoperative scolicidal solution. The side‐effects of its local application are not well known and have not been investigated. The purpose of the present study was to investigate the effects of the intracystic injections of alcohol and albendazole solutions on the hydatid cysts and hepatobiliary system of rabbits. Methods:  There were three groups of eight rabbits: a control group, an alcohol group and an albendazole group. In all groups hepatic hydatidosis was obtained. The control group received no therapeutic procedure. Cyst liquid was aspirated, and alcohol or albendazole solutions were injected in the other two study groups. alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ‐glutamyl transferase (GGT) levels, echinococcus indirect hemagglutination (IHA) tests, and the size and volume of the residual cysts were investigated. Liver was histopathologically evaluated. Results:  The ALT, AST, GGT, and alkaline phosphatase (ALP) levels were significantly higher in the alcohol group, whereas echinococcus IHA level was highest in the control group than in the study groups. Albendazole had similar effects but of a lesser degree (P