Cell cycle, DNA replication, repair, and recombination in the dimorphic human pathogenic fungus Paracoccidioides brasiliensis

DNA replication, together with repair mechanisms and cell cycle control, are the most important cellular processes necessary to maintain correct transfer of genetic information to the progeny. These processes are well conserved throughout the Eukarya, and the genes that are involved provide essentia...

Full description

Saved in:
Bibliographic Details
Published in:Genetics and molecular research 2005-01, Vol.4 (2), p.232-250
Main Authors: Reis, Viviane Castelo Branco, Torres, Fernando Araripe Gonçalves, Poças-Fonseca, Marcio José, De-Souza, Marlene Teixeira, Souza, Diorge Paulo de, Almeida, João Ricardo Moreira, Marinho-Silva, Camila, Parachin, Nádia Skorupa, Dantas, Alessandra da Silva, Mello-de-Sousa, Thiago Machado, Moraes, Lídia Maria Pepe de
Format: Article
Language:English
Subjects:
Cell Cycle - genetics
Cell Cycle - physiology
DNA Repair - genetics
DNA Repair - physiology
DNA Replication - genetics
DNA Replication - physiology
DNA, Fungal - genetics
Genes, Fungal - genetics
Humans
Mutation - genetics
Paracoccidioides - cytology
Paracoccidioides - genetics
Paracoccidioides brasiliensis
Recombination, Genetic - genetics
Recombination, Genetic - physiology
Saccharomyces cerevisiae
Transcription, Genetic - genetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:DNA replication, together with repair mechanisms and cell cycle control, are the most important cellular processes necessary to maintain correct transfer of genetic information to the progeny. These processes are well conserved throughout the Eukarya, and the genes that are involved provide essential information for understanding the life cycle of an organism. We used computational tools for data mining of genes involved in these processes in the pathogenic fungus Paracoccidiodes brasiliensis. Data derived from transcriptome analysis revealed that the cell cycle of this fungus, as well as DNA replication and repair, and the recombination machineries, are highly similar to those of the yeast Saccharomyces cerevisiae. Among orthologs detected in both species, there are genes related to cytoskeleton structure and assembly, chromosome segregation, and cell cycle control genes. We identified at least one representative gene from each step of the initiation of DNA replication. Major players in the process of DNA damage and repair were also identified.
ISSN:1676-5680
1676-5680