Electroencephalographic spectral power in writer's cramp patients: Evidence for motor cortex malfunctioning during the cramp

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2005-09, Vol.27 (3), p.706-714
• Main Authors: Kristeva, Rumyana, Chakarov, Vihren, Losch, Florian, Hummel, Sibylla, Popa, Traian, Schulte-Mönting, Jürgen
• Format: Article
• Language: English
• Subjects: Adult; Brain; Data Interpretation, Statistical; Dystonic Disorders - physiopathology; EEG; Electroencephalography; Electromyography; Electrooculography; EMG; Female; Fingers - physiology; Functional Laterality - physiology; Handwriting; Humans; Hypotheses; Isometric Contraction - physiology; Male; Middle Aged; Motor Cortex - physiopathology; Muscle Contraction - physiology; Psychomotor Performance - physiology; Somatosensory Cortex - physiopathology; Spectral power; Studies; Telephone companies; Writer's cramp; Writers; Writing
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2005.05.004

We investigated cortical activation as reflected in task-related spectral power (TRPow) changes in 8 writer's cramp patients during writing on a digital board and during isometric contraction and compared them to those of 8 age-matched healthy subjects. Scalp EEG was recorded over the contralateral primary sensorimotor area (SM1 c), and from the ipsilateral sensorimotor area (SM1 i). The electromyogram (EMG) was recorded from the Extensor Digitorum Communis (Extensor), Flexor Digitorum Superficialis (Flexor), and First Dorsal Interosseous (FDI) muscles. We analyzed (1) handwriting performance, (2) changes in the TRPow confined to alpha and beta band, and (3) the EMG spectral power during both tasks, writing and isometric contraction. During writing, all patients developed writer's cramp. The handwriting in writer's cramp patients was associated with significantly less reduction of the beta-range TRPow and lower frequency of the TRPow reduction compared to controls. No significant differences between patients and controls for the alpha band TRPow reduction during handwriting were observed. During writing, the patients showed higher EMG spectral power than the controls but this difference was at the border of significance. The present results indicate disorder in the motor execution system, in writer's cramp patients, associated with impaired functional beta-network state of the contra- and ipsilateral sensorimotor cortices, most probably due to inadequate modulation of the intracortical inhibition associated with writing.