Effects of phosphatidylserine coatings on titanium on inflammatory cells and cell-induced mineralisation in vitro

Ideally an active bone biomaterial should increase the mineralisation rate at the bone healing sites, keeping at the same time the inflammation process to levels required for tissue regeneration. Our studies suggest that in addition to improving the nucleation process for new bone formation, coating...

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Bibliographic Details
Published in:Biomaterials 2005-12, Vol.26 (36), p.7572-7578
Main Authors: Bosetti, Michela, Lloyd, Andrew W., Santin, Matteo, Denyer, Steve P., Cannas, M.
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Bone and Bones - metabolism
Bone Regeneration
Bone Substitutes - chemistry
Calcium - metabolism
Cells, Cultured
Coated Materials, Biocompatible - chemistry
Fluoresceins - chemistry
Fluoresceins - metabolism
Guided Tissue Regeneration
Humans
In Vitro Techniques
Inflammation
Leukocytes, Mononuclear - metabolism
Macrophages - cytology
Macrophages - metabolism
Microscopy, Electron, Scanning
Mineralisation
Monocytes - cytology
Monocytes - metabolism
Osseointegration
Osteoblasts - cytology
Osteoblasts - metabolism
Phosphatidylserine
Phosphatidylserines - chemistry
Phospholipids - chemistry
Titanium
Titanium - chemistry
Wound Healing
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Summary:Ideally an active bone biomaterial should increase the mineralisation rate at the bone healing sites, keeping at the same time the inflammation process to levels required for tissue regeneration. Our studies suggest that in addition to improving the nucleation process for new bone formation, coating titanium with phospholipids may reduce the inflammatory response, which was shown to vary depending on the formulation employed. As phosphatidylserine reduced the inflammatory response to the greatest extent, in the second part of this study we examined its effect on osteoblast mineralisation. These studies demonstrated that phosphatidylserine improves the nucleation process for bone formation, by promoting the formation of bone-like tissue, so the high mineralisation potential of phosphatidylserine-coated titanium, together with the lower level of inflammatory response, supports the further development of this technology for coating osteointegrative devices.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2005.05.033