A Non-invasive, in Vivo Technique for Monitoring Vascular Status of Glioblastoma during Angiogenesis

The growth of solid tumors dependent on the process of angiogenesis in which growth factors secreted by tumor and stromal cells promote endothelial cell proliferation, migration, and maturation. This process generates a tumor-specific vascular supply and enables small or dormant tumors to grow rapid...

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Bibliographic Details
Published in:Technology in cancer research & treatment 2007-12, Vol.6 (6), p.641-650
Main Authors: Saxena, Vishal, Gonzalez-Gomez, Ignacio, Laug, Walter E
Format: Article
Language:English
Subjects:
Algorithms
Animals
Biological and medical sciences
Brain Neoplasms - blood supply
Brain Neoplasms - metabolism
Cell Line, Tumor
Female
Glioblastoma - blood supply
Glioblastoma - metabolism
Humans
Magnetic Resonance Imaging
Medical sciences
Mice
Mice, Nude
Models, Theoretical
Neovascularization, Pathologic - diagnosis
Neurology
Optics and Photonics
Oxyhemoglobins - analysis
Spectroscopy, Near-Infrared - methods
Tumors of the nervous system. Phacomatoses
Water - analysis
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Summary:The growth of solid tumors dependent on the process of angiogenesis in which growth factors secreted by tumor and stromal cells promote endothelial cell proliferation, migration, and maturation. This process generates a tumor-specific vascular supply and enables small or dormant tumors to grow rapidly with exponential increases in tumor volume. Determination of tumor oxygenation at the microvascular level will provide important insight into tumor growth, angiogenesis, necrosis, and therapeutic response, and will facilitate to develop protocols for studying tumor behavior. A non-invasive multi-modality approach based on near infrared spectroscopy (NIRS) technique, namely: Steady State Diffuse Optical Spectroscopy (SSDOS) along with Magnetic Resonance Imaging (MRI) is applied for monitoring the concentration of oxyhemoglobin, deoxyhemoglobin and water within tumor region and for studying the vascular status of tumor and the patho-physiological changes that occur during angiogenesis. Since, the growth of solid tumors depends on the formation of new blood vessels, an association between intramural microvessel density (MVD) and tumor oxygenation is also investigated. The relative decrease in oxygenation value with tumor growth indicates that though blood vessels infiltrate and proliferate the tumor region, a hypoxic trend is clearly present.
ISSN:1533-0346
1533-0338
DOI:10.1177/153303460700600608