TPX or Not TPX?

An Aurora A regulatory module has been identified in two different proteins: TPX2 in Xenopus laevis and TPXL-1 in C. elegans. The diverse roles of these two proteins in spindle assembly leave us to beckon the true C. elegans TPX2 ortholog to center stage.

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Bibliographic Details
Published in:Molecular cell 2005-08, Vol.19 (4), p.431-432
Main Author: Karsenti, Eric
Format: Article
Language:English
Subjects:
Animals
Aurora Kinases
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - physiology
Cell Cycle Proteins - genetics
Cell Cycle Proteins - physiology
Microtubule-Associated Proteins - genetics
Microtubule-Associated Proteins - physiology
Neoplasm Proteins - genetics
Neoplasm Proteins - physiology
Nuclear Proteins - genetics
Nuclear Proteins - physiology
Phosphoproteins - genetics
Phosphoproteins - physiology
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - physiology
Sequence Homology
Xenopus Proteins - genetics
Xenopus Proteins - physiology
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Description
Summary:An Aurora A regulatory module has been identified in two different proteins: TPX2 in Xenopus laevis and TPXL-1 in C. elegans. The diverse roles of these two proteins in spindle assembly leave us to beckon the true C. elegans TPX2 ortholog to center stage.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2005.08.002